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Construction of up-conversion material combined signal quenching sensing device

A technology for converting materials and sensing devices, which is applied in the analysis of materials, electrochemical variables of materials, and material analysis by electromagnetic means. It can solve problems such as cell damage and human injury, and achieve low light damage, low cost, and high light stability. sexual effect

Active Publication Date: 2022-06-28
UNIV OF JINAN
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Problems solved by technology

[0002] At this stage, the probability of suffering from cancer is increasing, and the existing radiotherapy, chemotherapy and other methods will also cause serious damage to normal cells and cause irreversible damage to the human body while treating cancer

Method used

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Examples

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Embodiment Construction

[0019] In order to further understand the present invention, according to the technical solution of the present invention, the implementation is carried out in conjunction with the examples, and the specific embodiments are given:

[0020] (1) Synthesis of NaYF 4 :Yb,Er: Dissolve 1.176 g of trisodium citrate in 5 mL of water, then add 1 mmol of Ln(NO 3 ) 3 (74.4% Y 3+ , 25% Yb 3+ , 0.1% Er 3+ ) and 3 g NaNO 3 , and stirred for 20 min; after that, sodium fluoride solution (0.252 g NaF dissolved in 5 mL of water) was added and stirred well; the above solution was transferred to a 20 mL polytetrafluoroethylene-lined autoclave and heated at 180 °C for 12 h; the product was then isolated by centrifugation and further washed with water and ethanol; finally, it was dried in a vacuum oven at 60 °C overnight.

[0021] (2) Synthesis of NaYF 4 :Yb, Er@Bi 2 MoO 6 @Bi: put 5.0 mmol Bi (NO 3 ) 3 ·5H 2 O and 0.1 g of step (1) and synthesized product were transferred into 10 mL of...

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PUM

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Abstract

The invention discloses a construction method of an up-conversion material combined signal quenching sensing device, which is characterized in that NaYF4: Yb, Er (at) Bi2MoO6 (at) Bi which can be excited by near-infrared light and has good photoelectrochemical signals is synthesized, and NaYF4: Yb and Er are used as one of the up-conversion materials and have excellent light transmission, low light damage and high light stability; meanwhile, in NaYF4: Yb, Er (at) Bi2MoO6 (at) Bi, plasma Bi serves as an optical concentrator and an energy conveyor, and the absorption cross section and the interface energy of an up-conversion system can be effectively improved; the sensing system is excited by near-infrared light, and the near-infrared light has the advantages of low phototoxicity and corrosivity and minimum photobleaching; in addition, Au (at) CeO2 is modified on the second antibody to serve as a signal amplification carrier, electron transfer can be effectively hindered and light current can be reduced through the steric hindrance effect brought by introduction of a second antibody marker Au (at) CeO2, meanwhile, Au (at) CeO2 can also serve as simulated peroxidase to effectively catalyze 4-chloro-1-naphthol to generate corresponding precipitates, the light current is further reduced, and the sensitivity of the sensor is improved.

Description

Technical field [0001] The present invention relates to the field of quantitative detection of prostate-specific antigen, and more specifically to the construction of an upconversion material combined with a signal quenching sensor device. Background technique [0002] At this stage, the probability of suffering from cancer is increasing, and existing radiotherapy, chemotherapy and other methods can also cause serious damage to normal cells while treating cancer, causing irreversible damage to the human body. Therefore, achieving early detection and treatment of cancer is of great significance to the diagnosis of malignant tumors. Establishing a new method for detecting malignant tumor biomarkers that is simple, rapid, sensitive and selective is of great significance for the early detection and treatment effect evaluation of malignant tumors. Has very important value. [0003] Upconverting nanoparticles have properties such as low photodamage, stable chemical composition, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327G01N27/416G01N33/542G01N33/574
CPCG01N27/305G01N27/3275G01N27/3278G01N27/416G01N33/542G01N33/57434G01N33/57473Y02E10/542
Inventor 颜梅苗培张晶秦成坤马廷滨刘明霞吕艳锋
Owner UNIV OF JINAN
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