Nifedipine controlled release tablet and preparation method thereof

A technology of nifedipine and nifedipine, which is applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of frequent doses, fluctuations in blood drug concentration, and fatigue, etc., so as to reduce the number of doses, Good internal and external correlation, the effect of improving safety
CN114681422APending Publication Date: 2022-07-01HYBIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HYBIO PHARMA
Publication Date
2022-07-01

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Abstract

The invention discloses a nifedipine controlled release tablet and a preparation method thereof. The nifedipine controlled release tablet comprises a tablet core, a coating wrapping the tablet core and a gastric-soluble film coating wrapping the coating, the tablet core comprises a drug-containing layer I, a drug-containing layer II and a boosting layer which are arranged in sequence, and a drug release hole is formed in one side of the drug-containing layer I of the coating. A three-chamber push-pull osmotic pump controlled release technology is adopted, nifedipine is rapidly released within 4 hours after being taken through the drug-containing layer I and reaches the effective blood concentration, after the effective blood concentration is reached, the drug-containing layer II starts to release drugs, and the characteristic of zero-order release is maintained within the next 20 hours, so that the nifedipine sustained release tablet is prepared. And the blood concentration is kept in an effective blood concentration range.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to a nifedipine controlled-release tablet and a preparation method thereof. Background technique

[0002] Nifedipine is a dihydropyridine calcium channel antagonist. This product can dilate the coronary arteries in the normal blood supply area and ischemic area at the same time, antagonize spontaneous or ergometrine-induced coronary artery spasm, and increase myocardial oxygenation in patients with coronary artery spasm. Deliver, relieve and prevent coronary spasm; can inhibit myocardial contraction, reduce myocardial metabolism, reduce myocardial oxygen consumption; dilate peripheral resistance blood vessels, reduce peripheral resistance, reduce systolic and diastolic blood pressure, and reduce cardiac afterload. It is commonly used clinically for various types of angina pectoris (especially variant angina pectoris), hypertension, refractory congestive heart failure and oth...

Claims

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