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Nickel-titanium alloy wire, preparation method thereof and stent

A technology of nickel-titanium alloy and titanium alloy wire is applied in the field of vascular stent materials and its preparation, which can solve problems such as carcinogenic risk, and achieve the effects of reducing dependence, easy control, and simple preparation method.

Pending Publication Date: 2022-07-15
深圳海医达高分子科技有限公司
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  • Summary
  • Abstract
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  • Claims
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Problems solved by technology

However, its long-term implantation in the body has the following disadvantages: 1. The molecules of nickel-titanium alloy are precipitated, especially the precipitation of nickel, which has the risk of carcinogenesis; 2. Nickel-titanium alloy has blood coagulation properties, and long-term anticoagulation is required after implantation blood drug

Method used

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  • Nickel-titanium alloy wire, preparation method thereof and stent
  • Nickel-titanium alloy wire, preparation method thereof and stent
  • Nickel-titanium alloy wire, preparation method thereof and stent

Examples

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preparation example Construction

[0027] The preparation method of the stent of the present invention comprises the following steps:

[0028] Step 1. Preprocessing

[0029] At room temperature (20°C±5°C), place Nitinol wire with a wire diameter of 0.03-0.5mm and a length of 10-500m directly in a pretreatment solution of 20-60°C for 1-4 hours to obtain Pretreated Nitinol wire.

[0030] The pretreatment solution is 5% sodium hydroxide solution.

[0031] The surface of the nickel-titanium alloy wire is pretreated with a pretreatment solution to make the surface rough, which is convenient for subsequent coating of the PEEK coating layer and increases the adhesion.

[0032] In this embodiment, the wire diameter is measured by the LMD-DXYG laser caliper of Sichuan Huihuang Measurement and Control Equipment Co., Ltd., and the HRJSJ-4m stainless steel cooling water tank of Foshan Hairuijia Precision Extrusion Machinery Co., Ltd., 2000*500*300mm glass or ceramic sink for immersion.

[0033] Step 2. Cleaning

[003...

Embodiment 1

[0067] Example 1 Test Substance 1 Test Tube Absorbance=0.023,

Embodiment 2

[0068] Example 2 Test substance 1 Test tube absorbance=0.010,

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Abstract

The invention discloses a nickel-titanium alloy wire, a preparation method of the nickel-titanium alloy wire and a stent. The technical problem to be solved is to reduce the risk of implanting a heart stent and a heart occluder. The nickel-titanium alloy wire adopts the following technical scheme that the wire diameter of the nickel-titanium alloy wire is 0.03-0.5 mm, and a polyether-ether-ketone coating layer with the thickness not exceeding 0.1 mm is coated outside the nickel-titanium alloy wire. The preparation method comprises the following steps: pretreatment, cleaning, preheating and coating. The stent is prepared from the nickel-titanium alloy wire, and the nickel-titanium alloy wire is the nickel-titanium alloy wire coated with the polyether-ether-ketone and prepared by the preparation method disclosed by the invention. Compared with the prior art, the nickel-titanium alloy wire coated with the polyether-ether-ketone is adopted for manufacturing the stent, nickel precipitation of the stent can be effectively reduced, dependence of a patient on an anticoagulant drug is reduced, the risk of implantation of a heart stent and a heart occluder is reduced, and the preparation method of the nickel-titanium alloy wire coated with the polyether-ether-ketone is simple, easy to control and suitable for industrial production; the cost is low.

Description

technical field [0001] The present invention relates to a medical device material used in vascular intervention operation, a preparation method thereof, and a stent using the medical device material, in particular to a vascular stent material, a preparation method thereof, and a stent using the material. Background technique [0002] Stents are used in vascular interventional surgery. They are placed in the diseased segment of the blood vessel, and an inner stent is formed in the blood vessel to support the narrowed and occluded blood vessel, reduce the elastic retraction and remodeling of the blood vessel, and maintain the smooth blood flow of the blood vessel cavity. Since the stent made of nickel-titanium alloy was applied and implanted into the human body in the 1880s, its comprehensive performance has been continuously improved with the higher requirements of patients on the quality of life. Nitinol wire is widely used in various stents and cardiac occluders implanted i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82B29C48/05B29C48/154B29C48/92
CPCA61F2/82B29C48/05B29C48/154B29C48/92A61F2240/001A61F2210/0014B29C2948/92704B29C2948/926
Inventor 蒋志刚
Owner 深圳海医达高分子科技有限公司
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