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Hydrogel constructed synergistically by macromolecular self-assembly and metal coordination

A metal coordination and hydrogel technology, which is applied in the field of biomedical polymer materials to achieve the effect of improving biocompatibility and uniform network structure

Pending Publication Date: 2022-07-22
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of macromolecule self-assembly and the hydrogel that metal coordination cooperates to construct, to solve the defect that hydrogel exists in the prior art

Method used

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  • Hydrogel constructed synergistically by macromolecular self-assembly and metal coordination
  • Hydrogel constructed synergistically by macromolecular self-assembly and metal coordination
  • Hydrogel constructed synergistically by macromolecular self-assembly and metal coordination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of PAM hydrogels

[0024] Add 1.0 g of acrylamide to 5 mL of 0.1 mol / L NaOH solution by ultrasonic to completely dissolve it, then add 2.0 mg of N,N'-bis(acryloyl) cystamine for ultrasonic treatment for 5 min, and add 3.0 mg of 2-hydroxy- 4'-(2-hydroxyethoxy)-2-methylpropiophenone, and then ultrasonically treated for 5 min to form a mixed solution; the obtained mixed solution was irradiated under a high pressure ultraviolet lamp for 30 min to prepare PAM hydrogel.

[0025] The PAM hydrogel prepared by this process was tested by a universal testing machine, and its tensile strength was 0.21MPa, Young's modulus was 4.79KPa, and the tensile length at break was about 1380%. The tensile-adhesion test shows that the adhesion strength between it and pigskin is 0.56KPa.

Embodiment 2

[0027] 1. Preparation of casein nanomicelles

[0028] Add 0.75 g of casein powder to 5 mL of 0.1 mol / L NaOH solution, and magnetically stir overnight to obtain a casein micelle solution;

[0029] 2. Preparation of CS-PAM hydrogels

[0030] To the obtained casein micelle solution, add 1.0 g of acrylamide and ultrasonically to dissolve it completely, then add 2.0 mg of N,N'-bis(acryloyl) cystamine and ultrasonically for 5 min, and then add 3.0 mg of 2-hydroxy-4'-( 2-Hydroxyethoxy)-2-methylpropiophenone was ultrasonicated for 5 min to form a mixed solution; the obtained mixed solution was irradiated under a high pressure ultraviolet lamp for 30 min to prepare a hydrogel.

[0031] The CS-PAM hydrogel prepared by this process was tested by the test method provided in Example 1. The measured tensile strength of the obtained hydrogel was 1.78MPa, the Young's modulus was 154KPa, and the tensile length at break was about 1600 MPa. %, and the adhesion strength with pigskin is 12.14KPa...

Embodiment 3

[0033] 1. Preparation of nanocomposite crosslinking agent

[0034] First, 0.75 g of casein powder was added to 5 mL of 0.1 mol / L NaOH solution, and magnetically stirred overnight to obtain a casein micelle solution. Next, 200 μL of 0.05 mg / mL silver nitrate aqueous solution was added to the casein micelle solution, and the CS / Ag aggregate solution was obtained by magnetic stirring for 30 min. Then, 2.0 mg of N,N'-bis(acryloyl)cystamine was added and ultrasonicated for 10 min to obtain a nanocomposite crosslinking agent solution.

[0035] 2. Preparation of CS / Ag / BACA-PAM hydrogels

[0036] To the nanocomposite crosslinking agent solution prepared above, add 1.0g acrylamide ultrasonically to make it completely dissolved, then add 3.0mg 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone ultrasonically 5 min, a mixed solution was obtained; the obtained mixed solution was irradiated under a high pressure ultraviolet lamp for 30 min to prepare a hydrogel.

[0037] The PAM hydro...

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Abstract

The invention discloses hydrogel synergistically constructed by macromolecular self-assembly and metal coordination, and relates to the field of biomedical high polymer materials, and the hydrogel is prepared by the following steps: firstly, preparing nano-scale spherical casein micelles with negative charges on the surface by utilizing the characteristic that casein can be self-assembled into micelles in an aqueous solution; secondly, metal ions are added and reassembled with the casein micelles to form a spherical aggregate with the metal ions on the surface; and then adding an organic small molecule compound containing disulfide bonds to generate dynamic coordination bonds with metal ions, thereby preparing the nanoscale micelle cross-linking agent. And finally, introducing the nano-micelle cross-linking agent into a monomer solution, and constructing the high-strength multifunctional hydrogel with a uniform internal structure under the induction of ultraviolet light. The hydrogel obtained in the invention has excellent biocompatibility and relatively high adaptability, and is a multifunctional hydrogel with great medical potential.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, in particular to a hydrogel with self-assembly and metal coordination. Background technique [0002] Hydrogels are semi-solid materials with a three-dimensional network structure composed of polymer chains that are cross-linked together. They have porous network structures with pore sizes ranging from macro to nano-sized. The hydrogel network swells rapidly in water but is insoluble in water, endowing the hydrogel with both solid-like mechanical properties and liquid-like exchange and transport properties. Due to the hydrophilic nature of the constituent structures, large amounts of water can be absorbed and stored in the structural voids, making hydrogels highly similar to biological tissues, allowing certain specific molecules, such as salt ions, growth factors, proteins, and biological Active drugs, etc. passed. These properties make hydrogels have broad application prospects in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L89/00C08L33/26
CPCC08J3/075C08J2389/00C08J2433/26
Inventor 刘欢欢李晓侠王敏
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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