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Hemostatic device, hemostatic coating dispersion and hydrophobic surface

A hydrophobic surface and dispersion technology, applied in bandages, surgery, drug delivery, etc., can solve problems that have not been solved well, and achieve the effect of preventing wound infection, reducing blood loss, and preventing blood loss

Pending Publication Date: 2022-07-22
NAT UNIV OF SINGAPORE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, the above two key challenges regarding wound management remain poorly addressed

Method used

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  • Hemostatic device, hemostatic coating dispersion and hydrophobic surface
  • Hemostatic device, hemostatic coating dispersion and hydrophobic surface
  • Hemostatic device, hemostatic coating dispersion and hydrophobic surface

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Embodiment Construction

[0144] Described with reference to the drawings are hydrophobic surfaces, hemostatic dispersions, and hemostatic devices for achieving hemostasis. Some embodiments of these surfaces, dispersions and devices aim to achieve rapid blood coagulation prior to massive blood loss and subsequent easy removal of wound dressings without clot tearing and secondary bleeding. These goals are achieved by superhydrophobic (SHP) surfaces with immobilized carbon nanofibers (CNFs).

[0145] Here we show that CNF can promote rapid fibrin growth and lead to rapid coagulation. Furthermore, due to their superhydrophobic properties, they severely limit the wetting of blood to prevent blood loss and greatly reduce bacterial attachment. Furthermore, minimal contact between the clot and the superhydrophobic CNF surface produced non-forced clot shedding after clot retraction.

[0146] These important properties were verified in vitro and in vivo by rat experiments. Therefore, the following work shows...

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Abstract

Hemostatic devices are described that include a substrate and a surface formed on the substrate. The surface includes at least one of a micromaterial and a nanomaterial, the material being partially embedded in the matrix, the surface substantially preventing wetting of the substrate.

Description

technical field [0001] The present invention relates to hemostatic coating dispersions, hydrophobic surfaces formed using the same, and hemostatic devices. The present invention relates to, but is not limited to, hemostatic patches for wound treatment. Background technique [0002] In the medical field of wound care, uncontrolled bleeding and wound infection are the leading causes of death. Improper dressing of wounds prolongs healing time and carries a high risk of infection, resulting in a substantial increase in mortality and economic burden. Therefore, hemostatic materials are of great importance in medicine for the successful repair and treatment of wounds. [0003] Their successful implementation depends on two often competing attributes: a) the rapid achievement of blood coagulation prior to massive blood loss; and, b) the ability to subsequently easily remove the wound dressing without clot tearing and secondary bleeding. The traditional way to manage bleeding is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/52
CPCA61L15/52A61L15/18A61L2400/12A61L15/42A61L15/34A61L15/24A61L31/126A61L31/14A61L2400/04C08L83/04C08L27/18C08L91/06
Inventor 叶俊淮李哲D·普莉卡克斯A·米尼奥斯
Owner NAT UNIV OF SINGAPORE