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Method for recovering ginkgolic acid from ginkgo leaf extract production waste residues

A technology of ginkgo phenolic acid and ginkgo biloba leaves, which is applied in the fields of botanical equipment and methods, plant growth regulators, chemicals for biological control, etc., can solve problems such as pollution, increase social wealth, etc. Fast-growing, easy-to-use effects

Pending Publication Date: 2022-07-29
贵州北极兴药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a method for recovering ginkgophenolic acid from ginkgo leaf extract production waste residue, so as to improve the comprehensive utilization rate of ginkgo leaves, solve the problem of waste pollution, and at the same time make it turn waste into wealth and harm into profit , increase social wealth and promote economic development

Method used

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  • Method for recovering ginkgolic acid from ginkgo leaf extract production waste residues
  • Method for recovering ginkgolic acid from ginkgo leaf extract production waste residues
  • Method for recovering ginkgolic acid from ginkgo leaf extract production waste residues

Examples

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Effect test

Embodiment 1

[0025] Take 104.8kg of ginkgo biloba extract production waste residue as raw material, add 300L of methanol and stir to dissolve, after centrifugation, the filtrate is extracted with 300L of petroleum ether, after 75L of water is added, layered, the petroleum ether layer is concentrated to paste, dissolved in 150L of 65% ethanol, and then enlarged The porous resin column is washed with 65% ethanol of 3BV resin volume, and then eluted with 90% ethanol of 5BV resin volume, and the eluent is concentrated to obtain an extract with a ginkgolic acid content greater than 75%. Using ginkgo acid as the standard sample, the content of ginkgo phenolic acid was determined by HPLC. The results showed that the content of ginkgo phenolic acid in the waste residue of Ginkgo biloba extract was extracted from 17% and then concentrated to obtain 31.5kg of extract with ginkgolic acid content of 52.6%. , 20.3kg of extract with 78% ginkgo phenolic acid content was obtained after purification by resi...

Embodiment 2

[0027] Take 102.4kg of ginkgo biloba extract production waste residue as raw material, add 400L of methanol and stir to dissolve, after centrifugation, the filtrate is extracted with 400L of dichloromethane, replenished with 135L of water, the organic layer is concentrated to a paste, dissolved in 150L of 70% ethanol and placed on a macroporous resin column , wash impurities with 1.5BV resin volume of 70% ethanol, and then use 3BV resin volume of 95% ethanol to elute, and concentrate the eluent to obtain an extract with a ginkgolic acid content greater than 75%. Taking ginkgoxin as the standard sample, the content of ginkgo phenolic acid was determined by HPLC. The results showed that the content of ginkgo phenolic acid in the waste residue of Ginkgo biloba extract was extracted from 17% and then concentrated to obtain 32.4kg of extract with 51.5% ginkgo phenolic acid content. , and then purified by resin column to obtain 19.5kg of extract with ginkgolic acid content of 79.4%. ...

Embodiment 3

[0029] Take 107.2 kg of ginkgo biloba extract production waste residue as raw material, add 500 L of methanol and stir to dissolve, centrifuge the filtrate, extract with 500 L of ethyl acetate, add 1000 L of water and concentrate the organic layer to paste, dissolve with 150 L of 70% ethanol, and apply a macroporous resin The column is washed with 70% ethanol of 2BV resin volume, and then eluted with 95% ethanol of 4BV resin volume, and the eluent is concentrated to obtain an extract with a ginkgolic acid content greater than 75%. Taking ginkgo acid as the standard sample, the content of ginkgo phenolic acid was determined by HPLC. The results showed that the content of ginkgo phenolic acid in the waste residue of Ginkgo biloba extract was extracted from 17% and then concentrated to obtain 33.8kg of extract with ginkgolic acid content of 53.1%. , and then purified by resin column to obtain 22.1kg of extract with ginkgolic acid content of 77.2%.

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Abstract

The invention relates to a method for recovering ginkgolic acid from ginkgo leaf extract production waste residues, which comprises the following steps of: (1) taking ginkgo leaf production extract alcohol extract, concentrating to remove alcohol, standing and precipitating residues as a raw material, dissolving by using methanol, centrifuging, extracting filtrate by using an extracting agent with the same volume, replenishing water until layering, and concentrating an extracted organic liquid layer into extract; (2) dissolving the extract with an ethanol solution, uniformly stirring, centrifuging, and taking supernate for later use; (3) filling the treated resin into an adsorption column, and ensuring that the resin is filled uniformly without bubbles; loading the supernate on a loaded resin adsorption column; removing impurities by using 1-3BV of an ethanol solution after the reaction is finished; and eluting with an ethanol solution of 1-5BV, collecting the eluent, and carrying out vacuum concentration to obtain an extract, namely the purified ginkgolic acid extract. The invention lays a foundation for promoting the rapid development of gingko planting and processing industry, increasing the economic income of people and increasing a novel biopesticide for the market, thereby having obvious economic, environmental and social benefits.

Description

technical field [0001] The present invention relates to alkylphenols and alkylphenolic acids in organic compounds, in particular, to ginkgolic acid; further, to a method for recovering ginkgolic acid from waste residues produced by extracting Ginkgo biloba leaves. Background technique [0002] my country is extremely rich in ginkgo resources, accounting for about 80% of the world's ginkgo resources. Ginkgo biloba L., also known as Ginkgo biloba, with its own efficient defense system evolved through natural selection, is rarely damaged by pests and diseases during its growth, and this defense effect is related to the secondary chemicals it has. have a close relationship. It has been reported that the reason why ginkgo is rarely affected by diseases and insect pests is that the phenolic acid components of ginkgo leaves play a major role. But for a long time, people only paid attention to the medical value of ginkgo, but ignored the application in agricultural pest control. ...

Claims

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Application Information

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IPC IPC(8): A01N65/06A01P7/00A01P3/00
CPCA01N65/00A01N65/06
Inventor 何珺陈伟王黔阳黄莉清
Owner 贵州北极兴药业有限公司
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