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Extraction method of L-alanine

An extraction method and technology of alanine, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as low crystallization rate, powdery crystal particles, and difficult crystallization of materials, so as to increase the total yield The effect of rate and purity

Pending Publication Date: 2022-07-29
ANHUI BBCA BIOCHEMICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the cost of producing L-alanine by fermentation is low, and it conforms to the concept of green and healthy consumption, it has broad market prospects; after the production of L-alanine by fermentation, the L-alanine is generally purified by multiple crystallization methods However, the methods such as concentration and crystallization of the existing extraction process cannot effectively improve the finished product yield of L-alanine. When the purity of the mother liquor is reduced to below 50%, the material is difficult to crystallize, the crystallization rate is low, and the crystal particles are Disadvantages such as powder

Method used

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  • Extraction method of L-alanine
  • Extraction method of L-alanine

Examples

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Embodiment 1

[0036] This embodiment provides a method for extracting L-alanine.

[0037] (1) 10m 3 Mother liquor (purity ≤50%) was added to 15m 3 Use pure water (conductivity≤20μs / cm) in the stainless steel storage tank to adjust the dry content to 220g / L, heat to 65°C by steam, use 30% liquid caustic soda to adjust the pH to 6.5-7.0, take samples for testing and reserve;

[0038] (2) Soak and wash the resin with deionized water repeatedly until the eluate is clear, and then soak with 2mol / L NaOH solution for about 24 hours. After washing with distilled water to neutrality, take the resin for use after washing to neutrality. 90 tons, packed into a Φ3300mm chromatographic column, 6 chromatographic columns are connected end to end, marked as No. 1-6 chromatographic columns, with a total length of 8600mm, the last chromatographic column and the first chromatographic column are connected end to end through a circulating pump , and each chromatographic column is also provided with two inlet p...

Embodiment 2-4

[0046] This embodiment provides a method for extracting L-alanine.

[0047] Referring to Example 1, three different mother liquors were selected for extraction.

Embodiment 5

[0049] This embodiment provides a method for extracting L-alanine.

[0050] Referring to Example 1, the mother liquor with a purity of 32.07% was selected for extraction.

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Abstract

The invention provides an extraction method of L-alanine. The extraction method comprises the following steps: purifying the L-alanine mother liquor by using a circulating chromatography system to obtain an extracting solution; wherein the purity of the L-alanine contained in the L-alanine mother liquor is 30 to 80 percent, and preferably, the purity of the L-alanine contained in the L-alanine mother liquor is 30 to 50 percent. The extraction method of the L-alanine provided by the invention can be used for extracting the mother liquor of the L-alanine with the purity of 50% or below, and the total extraction yield and purity of the L-alanine can be improved.

Description

technical field [0001] The invention belongs to the technical field of L-alanine production, and relates to a method for extracting L-alanine. Background technique [0002] Although alanine is a non-essential amino acid, it is the amino acid with the highest content in human blood and can provide amino donors for transaminase. It is often added to infusion in clinical practice; in the food industry, L-alanine It can be used as a sweetener and umami agent, and is more and more popular and valued by people; in the pharmaceutical industry, L-alanine is an important raw material for the production of vitamin B6 and L-amino acid propanol. In terms of polymer materials, adding L-alanine to polylactic acid can effectively improve the performance of polylactic acid, and its future market potential is immeasurable. [0003] The production methods of L-alanine mainly include protein hydrolysis extraction, fermentation extraction, and enzyme conversion production. Because the cost of...

Claims

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Application Information

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IPC IPC(8): C07C227/40C07C229/08
CPCC07C227/40C07B2200/07C07C229/08
Inventor 朱亮付松崔怀成冯学磊王瑞昌闻龙
Owner ANHUI BBCA BIOCHEMICAL CO LTD