Recycling method of extracting solvent of galangal dropping pill extract
A technology for extracting solvents and attaching dripping pills, which is applied in the field of reuse of extracting solvents of Liangfu dripping pills, can solve the problems of reduced transfer rate of galangin, lower yield of extracts, and inability to recycle ethyl acetate, etc. Achieve the effects of reducing storage difficulty, guaranteeing yield, and reducing production costs
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Embodiment 1～5
[0049] Proceed as follows:
[0050] 1) The ethyl acetate solvent obtained by distillation under reduced pressure is distilled and dried, and the steamed gas passes through Na 2 CO 3 solution to obtain a recovery solution;
[0051]2) The recovered solution obtained in step 1) is distilled under normal pressure, and the obtained fraction is collected at 77°C;
[0052] 3) adding a desiccant to the obtained fraction in a ratio of 1 g:100 mL, and filtering with a 0.45 m microporous membrane after shaking overnight to obtain a filtrate;
[0053] 4) measure the moisture content in the gained filtrate, repeat steps 2) to 3) when moisture content>5% until the moisture content in the gained filtrate is less than or equal to 5% and stop to obtain ethyl acetate for reuse;
[0054] 5) Mix the recycled ethyl acetate with the unused ethyl acetate solvent in a volume ratio of 3:1 to obtain a recycled ethyl acetate solvent.
[0055] The method reagents and moisture content determination re...
Embodiment 6
[0059] Embodiment 6 measures the refractive index of the obtained solvent
[0060] Measured by the method under Item 0622 of Chinese Pharmacopoeia 2020 Edition, Part 4, and the obtained circulating ethyl acetate solvent after the above method was extracted in Example 1. The refractive index is about 1.372 (n=5), which is in line with the Chinese Pharmacopoeia. The refractive index of ethyl acetate solvent is specified.
[0061] In the remaining examples, the obtained circulating ethyl acetate test results are similar to the results obtained in Example 1, and are not described here.
Embodiment 7
[0062] Example 7 Gas Chromatography Determination
[0063] Adopt the gas chromatography method under Item 0521 of 4 General Rules of Chinese Pharmacopoeia in 2020, to measure the obtained circulating ethyl acetate solvent in Example 1, and the obtained results are as follows figure 2 shown.
[0064] Depend on figure 2 The result shows that the relevant impurities in the obtained circulating ethyl acetate slightly increase. According to the peak area normalization method, the sum of the peak areas of each impurity is about 0.2% of the main peak area, which meets the limit requirement.
[0065] In the remaining examples, the obtained circulating ethyl acetate test results are similar to the results obtained in Example 1, and are not described here.
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