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Drug-loaded lignin nanosphere and preparation method thereof

A technology of lignin and nanospheres, which is used in pharmaceutical formulations, drug combinations, antitumor drugs, etc., can solve the problems of uneven morphology, poor dispersion, and insufficient drug release of lignin nanospheres, and achieve uniform morphology and dispersion. The effect of good performance and good drug release performance

Pending Publication Date: 2022-08-05
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, due to the complexity of the lignin structure, the prepared lignin nanospheres have disadvantages such as inhomogeneous morphology, poor dispersion and insufficient drug release.

Method used

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  • Drug-loaded lignin nanosphere and preparation method thereof
  • Drug-loaded lignin nanosphere and preparation method thereof
  • Drug-loaded lignin nanosphere and preparation method thereof

Examples

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Embodiment 1

[0027] The preparation method of the drug-loaded lignin nanospheres of the present embodiment includes the following steps:

[0028] (1) Dissolve 0.05 mg of syringaldehyde in 10 mL of absolute ethanol, prepare a solution with a concentration of 0.5 mg / ml, and ultrasonically disperse for 10 minutes.

[0029] (2) Weigh 0.020 g of lignin, dissolve it in syringaldehyde-ethanol solutions of different concentrations in 1, and ultrasonically disperse for 20 minutes.

[0030] (3) Filtration with 0.45 μm nylon to remove undissolved parts.

[0031] (4) Weigh 10 mg of the hydrophobic phenylboronate caged anticancer prodrug (paclitaxel prodrug) and dissolve it in 3.

[0032] (5) 5 ml of hydrophilic glucose oxidase (GOD) (200 U / mL) was dissolved in 50 ml of deionized water.

[0033] (6) At room temperature, 50 ml of deionized water in which glucose oxidase (GOD) was dissolved was added dropwise to the mixed solution of 4 with a peristaltic pump to prepare hollow nanospheres. Control the...

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Abstract

The invention belongs to the technical field of preparation of lignin nanospheres, and particularly relates to a drug-loaded lignin nanosphere with controllable morphology and particle size and good drug release property and a preparation method of the drug-loaded lignin nanosphere. The preparation method comprises the following steps: dissolving lignin in an antioxidant dissolving system, and carrying out ultrasonic dispersion, dropwise adding a hydrophilic glucose oxidase solution, freeze-drying and the like to obtain the drug-loaded lignin nanospheres. The drug-loaded lignin nanospheres prepared by the method have the characteristics of uniform morphology, good dispersibility, good drug release performance and the like.

Description

technical field [0001] The application belongs to the technical field of preparation of lignin nanospheres, and in particular relates to a drug-loaded lignin nanosphere with controllable morphology and particle size and good drug release properties and a preparation method thereof. Background technique [0002] Among many natural materials for preparing nanoparticles, lignin has attracted much attention as a "natural green raw material". Lignin is the only aromatic organic polymer compound in nature, non-toxic, biodegradable, and has a good application prospect in the field of biomedicine. At present, most of the lignin comes from the waste of pulp and paper industry, and the calorific value is recovered by burning, and the utilization rate is low. Utilizing low-cost and wide-ranging industrial lignin to develop functional materials with high added value can reduce the production cost of enterprises and reduce environmental pollution. [0003] However, due to the complexit...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61K9/14A61K47/30A61P35/00A61K31/337
CPCA61K9/146A61K38/443A61K31/337A61P35/00C12Y101/03004A61K2300/00Y02E50/30
Inventor 李静曾士乂章沈翀周敏霞赵会芳郭大亮童欣
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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