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Chroman type or chromene type meroterpenoid compound as well as extraction method and application thereof

A compound and heteroterpene technology, applied in the field of traditional Chinese medicine extraction, can solve the problem of no inhibitory effect and achieve the effect of enriching structural diversity

Pending Publication Date: 2022-08-05
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no inhibitory effect was found on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells

Method used

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  • Chroman type or chromene type meroterpenoid compound as well as extraction method and application thereof
  • Chroman type or chromene type meroterpenoid compound as well as extraction method and application thereof
  • Chroman type or chromene type meroterpenoid compound as well as extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The method for extracting chromane-type or chromene-type heteroterpenoids in Rhododendron xing'an comprises the following steps:

[0059] (1) with total dry weight being 12.9kg Xing'an Rhododendron branches and leaves as raw material, add volume concentration 95% ethanol aqueous solution (110L), reflux extraction 2 times, each extraction 2 hours, merge to obtain extract, reduce pressure recovery solvent, concentrate Then obtain 95% ethanol layer total extract (2.3kg);

[0060] (2) the total extract that obtains is dispersed in the water (12L) of 5.2 mass times, successively with 5 mass times of the volume of petroleum ether, ethyl acetate extraction, the extract is concentrated and reclaimed the solvent, respectively obtains the petroleum ether extraction concentrate, The concentrate (560 g) and the aqueous phase were extracted with ethyl acetate;

[0061] (3) The ethyl acetate extraction concentrate was separated by silica gel column chromatography, and the volume rat...

Embodiment 2

[0100] The method for extracting chromane-type or chromene-type heteroterpenoids in Rhododendron xing'an comprises the following steps:

[0101] (1) with total dry weight being 15kg Xing'an Rhododendron branches and leaves as raw material, add volume concentration 95% ethanol aqueous solution (120L), reflux extraction 2 times, each extraction 2 hours, merge to obtain extract, underpressure recovery solvent, after concentrating Obtain 95% ethanol layer total extract (2.5kg);

[0102](2) the total extract that obtains is dispersed in the water (13L) of 5.2 mass times, successively uses the petroleum ether of 5 mass times of volume, ethyl acetate extraction, the extraction liquid is concentrated to reclaim the solvent, obtains the petroleum ether extraction concentrate, respectively, The concentrate (600 g) and the aqueous phase were extracted with ethyl acetate;

[0103] (3) The ethyl acetate extraction concentrate was separated by silica gel column chromatography, and the volu...

Embodiment 3

[0108] The method for extracting chromane-type or chromene-type heteroterpenoids in Rhododendron xing'an comprises the following steps:

[0109] (1) with total dry weight being 20kg Xing'an Rhododendron branches and leaves as raw material, add volume concentration 95% ethanol aqueous solution (160L), reflux extraction 2 times, each extraction 2 hours, merge to obtain extract, underpressure recovery solvent, after concentrating Obtain 95% ethanol layer total extract (3.125kg);

[0110] (2) the total extract that obtains is dispersed in the water (16L) of 5 mass times, successively uses the petroleum ether, ethyl acetate extraction of 5 mass times of volumes, and the extract is concentrated and reclaimed the solvent, respectively obtains the petroleum ether extraction concentrate, The concentrate (750 g) and the aqueous phase were extracted with ethyl acetate;

[0111] (3) The ethyl acetate extraction concentrate was separated by silica gel column chromatography, and the volume...

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Abstract

The invention discloses chromane or chromene meroterpenoids as well as an extraction method and application thereof, belongs to the field of extraction of traditional Chinese medicines, and particularly relates to chromane or chromene meroterpenoids which are separated from rhododendron dauricum and are shown in general formulas (I), (II) and (III), isomers of the chromane or chromene meroterpenoids, isomers of the chromane or chromene meroterpenoids, isomers of the chromane or chromene meroterpenoids, isomers of the chromane or chromene meroterpenoids and isomers of the The invention provides a chromane type or chromene type meroterpenoid compound or a pharmaceutically acceptable salt of the chromane type or chromene type meroterpenoid compound, an extraction method of the chromane type or chromene type meroterpenoid compound, and the chromane type or chromene type meroterpenoid compound or a pharmaceutical composition containing the chromane type or chromene type meroterpenoid compound has an The structural diversity of active substances of the rhododendron dauricum is enriched, on the basis, a foundation is laid for carrying out related biological activity tests on subsequently obtained monomeric compounds, an active lead compound is provided for new drug development, and meanwhile, a theoretical basis is provided for deep research and development of rhododendron dauricum medicinal materials.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction, in particular to a chromane-type or chromene-type heteroterpenoid compound and an extraction method and application thereof, in particular to a chromane-type or chromene-type heteroterpenoid compound isolated from Rhododendron xinggan The extraction method thereof and the application in the preparation of anti-inflammatory drugs. Background technique [0002] Rhododendron dauricum L. is a semi-evergreen shrub of the genus Rhododendron of the family Ericaceae. It not only has high ornamental value and garden application value, but also has high medicinal value. It is mainly distributed in Heilongjiang, Liaoning, Jilin, Inner Mongolia and other places. The 2020 edition of the "Chinese Pharmacopoeia" records that the dried leaves of Rhododendron Xing'an are "Manshanhong", which is acrid in taste and cold in nature; it returns to the lung and spleen meridians, and has the effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/94C07D311/70A61K31/352A61P29/00
CPCC07D311/94C07D311/70A61P29/00Y02A50/30
Inventor 陈丽霞李华张娜孙德娟熊靓靓
Owner SHENYANG PHARMA UNIVERSITY
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