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Technique for producing compound of macrolide

A production process, macrolide technology, applied in the field of production of macrolide musk compounds, can solve the problems of rising production costs, environmental pollution, waste of raw materials, etc., to reduce the consumption of raw materials, reduce production costs, and reduce waste discharge Effect

Inactive Publication Date: 2004-10-27
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] In the disclosed method for the production of macrolide compounds, the main disadvantage is that they all do not effectively recycle the excess dibasic alcohol that evaporates during the esterification and polycondensation process and discard it as waste, This will inevitably cause a great waste of raw materials, increase production costs, and more importantly, cause environmental pollution.

Method used

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  • Technique for producing compound of macrolide

Examples

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Embodiment 1

[0037] 45kg fresh ethylene glycol, 80kgC 11 ~C 15 Add the mixed dicarboxylic acid and 2.0kg palmitic acid into the esterification polycondensation reactor, heat the material under the protection of nitrogen, start stirring at 100 ° C, and heat the material to 180 ~ 200 ° C within 4 ~ 6 hours, when the temperature rises When the temperature reaches 150°C, water begins to evaporate. When no water evaporates, the system pressure is slowly reduced to 3mmHg, and the excess ethylene glycol is distilled under reduced pressure. The distilled ethylene glycol is condensed and cooled to 80-90°C before entering Filtration—recycling in the adsorption container. There is a filter bag on the upper part of the container. The adsorption column is filled with granular activated carbon with a particle size of 2-3mm and a pH of 6.3. The bed size is 300×1200mm, and the operating temperature is 80-90°C. The operating pressure is 3mmHg, and the residence time is controlled to 25-30min. The materia...

Embodiment 2

[0040] 20.5kg of reclaimed ethylene glycol, 80kg of tridecanedioic acid and 3.2kg of palmitic acid obtained in 25kg of fresh ethylene glycol and the regeneration treatment in the embodiment are added in the polycondensation reactor, and the method for esterification and polycondensation is carried out according to the method of embodiment 1 Reaction, steaming out excess ethylene glycol, the distilled ethylene glycol is condensed and cooled to 80-90°C and collected in a filter-adsorption container, and the prepared polyester is subjected to depolymerization and cyclization, depolymerization and cyclization and subsequent refining and purification operating conditions With embodiment 1. While the depolymerization and cyclization was carried out, the recovery treatment system used in Example 1 was used to process the gained ethylene glycol solution. The pressure of the processing operation was normal pressure, and finally 21.6 kg of the ethylene glycol solution was obtained. The s...

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Abstract

A process for preparing macrocyclic lactone features that the alpha, omega-long-chain dicarboxylic acid and dibasic alcohol take part in esterifying and polycondensating reaction to generate linear polyester, and in the later phase of reaction, the distilling step for removing excess dibasic alcohol and the aibasic alcohol recovering-reclaiming step are combined. Its advantages are less enviornmental pollution, high effect on reclaiming diol and low cost.

Description

1. Technical field [0001] The invention relates to the field of manufacturing macrocyclic ester musk fragrances, in particular to a method for producing macrocyclic lactone musk compounds. 2. Background technology [0002] Macrocyclic lactone compounds are a very important class of musk fragrances. They have an aroma similar to natural musk, elegant and pure, and have a long-lasting fragrance. They are used as fixatives in various detergents, shampoos, hair care products, soaps, fragrances, etc. It has been widely used in the deployment of daily chemical essence. [0003] At present, the methods of esterification polycondensation, depolymerization and cyclization are used to produce macrolide compounds at home and abroad to obtain crude products, and then refined and purified to obtain products. The method comprises three process steps, namely, esterification and polycondensation steps, depolymerization and cyclization and refining and purification steps. The starting mate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D321/00C07D325/00
Inventor 王崇晖宋喜军解丽娟张艳丽
Owner CHINA PETROLEUM & CHEM CORP