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Magnesium zinc fructose diphosphate and its preparing process and application in preparing medicines

A technology of magnesium zinc diphosphate and diphosphoric acid, which is applied in the application field of medicine, can solve the problems of limited therapeutic effect of myocardial ischemia and no physiological activity, and achieves the effect of preventing and controlling pathological damage of cells and enhancing activity.

Inactive Publication Date: 2004-11-24
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cation of fructose-1,6-diphosphate sodium salt has no physiological activity, and its therapeutic effect on cerebral ischemia or brain dysfunction and myocardial ischemia is very limited.

Method used

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  • Magnesium zinc fructose diphosphate and its preparing process and application in preparing medicines
  • Magnesium zinc fructose diphosphate and its preparing process and application in preparing medicines
  • Magnesium zinc fructose diphosphate and its preparing process and application in preparing medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Take 70 grams of fructose-1,6-diphosphate sodium, put it in 110 grams of distilled water, stir until dissolved, prepare an aqueous solution with a mass percentage of 39%, slowly pass through a 732-type ion exchange column, collect the effluent, and React with zinc oxide and basic magnesium carbonate at a molar ratio of 2:1:1 at 45°C, slowly add 5.6 grams of zinc oxide and 6.9 grams of basic magnesium carbonate while stirring, and filter until the pH is 2.5 to 3.0. The filtrate was freeze-dried to obtain 63 grams of the fructose diphosphate magnesium zinc (1) compound of the present invention. The content of fructose-1,6-diphosphate was determined by highly specific enzymatic method, the metal ion content was determined by chemical method and atomic absorption method, and the moisture content was measured by Karl Fischer's method. The results are: fructose-1,6-diphosphate 75.1%, zinc 7.2%, magnesium 2.6%, water 15.0%. Press C 6 h 12 o 12 P 2 Mg 0.5 Zn 0....

Embodiment 2

[0032] Example 2 Take 1,000 grams of sodium fructose octahydrate-1,6-diphosphate, dissolve it in 1,800 grams of distilled water, stir until dissolved, prepare an aqueous solution with a mass percentage of 25%, slowly pass it through a Dowex-type ion exchange column, and collect the effluent , react with zinc oxide and basic magnesium carbonate at a molar ratio of 2:2:1, take 111 grams of zinc oxide and 70 grams of basic magnesium carbonate, add them slowly while stirring at 30°C, and react with it to pH4.5 Filtrate at ~5.0 hours, add the filtrate to 6 times the volume of ethanol, stir, centrifuge, recrystallize the obtained precipitate with ethanol, and finally dry the crystals to obtain the magnesium fructose diphosphate magnesium zinc (2) compound 670 of the present invention gram. The content of fructose-1,6-diphosphate was determined by highly specific enzymatic method, the metal ion content was determined by chemical method and atomic absorption method, and the moisture c...

Embodiment 3

[0033] Example 3 Take 200 grams of fructose-1,6-diphosphate sodium, place it in 450 grams of distilled water, stir until dissolved, prepare an aqueous solution with a mass percentage of 31%, slowly pass through a 732-type ion exchange column, collect the effluent, and Zinc oxide and basic magnesium carbonate are reacted at a molar ratio of 2:1:2. Take 15.8 grams of zinc oxide and 39.0 grams of basic magnesium carbonate, add them slowly while stirring at 35°C, and react with them to pH 4.5-5.0 Filtrate, and freeze-dry the filtrate to obtain 182 grams of fructose diphosphate magnesium zinc (3) compound of the present invention. The content of fructose-1,6-diphosphate was determined by highly specific enzymatic method, the metal ion content was determined by chemical method and atomic absorption method, and the moisture content was measured by Karl Fischer's method. The results are: Fructose-1,6-diphosphate 72.9%, Zinc 7.0%, Magnesium 5.1%, Water 15.0%. Press C 6 h 11 o 12 P ...

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Abstract

A magnesium zinc fructose-1,6-diphosphate is prepared from other metal salts of fructose bisphosphate through adsorbing metal ions by cationic exhange resin to become fructose-1,6-bisphosphoric acid, adding magnesium and zinc ions, and recrystallizing or freeze drying. The product can be used to prepare the medicines for treating cerebral ischemia (including cerebral disunction), myocardial ischemia and their associated diseases.

Description

technical field [0001] The present invention relates to a new compound fructose diphosphate magnesium zinc and its preparation method, and this new compound is used as an active ingredient in the treatment of cerebral ischemia or brain dysfunction and related diseases, improving immunity, and treating myocardial ischemia and related diseases application in medicine. Background technique [0002] The structural formula of fructose-1,6-diphosphoric acid (Fructose-1,6-Diphosphoric Acid) is as follows: [0003] [0004] In modern medicine, fructose-1,6-bisphosphate is an important intermediate of sugar metabolism in the human body, and has the function of regulating sugar metabolism. Fructose-1,6-bisphosphate can improve the energy metabolism of human tissues under ischemia and hypoxia conditions, provide energy for human tissue cells, and relieve cellular glucose metabolism disorders. However, fructose-1,6-bisphosphate itself is very unstable, and i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024C07H11/04
Inventor 翁文罗焕敏章佩芬高勤
Owner JINAN UNIVERSITY