Method for preparing high activity bone defect repairing material

A technology for repairing materials and bone defects, applied in the field of preparation of medical biomaterials, can solve the problems of difficult productization and inconvenient molding, and achieve the effect of easy processing and obvious effect.

Inactive Publication Date: 2005-05-18
南京大学医学院附属口腔医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PLA with a molecular weight of 650 is a liquid, which is inconvenient to form and difficult to produce

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Polyethylene glycol (average molecular weight 600) was mixed with lactide in a molar ratio of 1:30, polymerized at 200°C for 24 hours to obtain polylactic acid, which was pulverized below 0°C into polylactic acid powder. At low temperature, mix the powder and BMP evenly at a ratio of 1000:5, press it into a certain shape below 38°C, and implant it into the bone defect site. After three weeks, the bone formation is obvious, and the surrounding tissues have no inflammation. After 12 weeks, the X-ray photos and Hard tissue sections showed good osteogenesis.

Embodiment 2

[0014] Example 2: Polyethylene glycol (average molecular weight 400) was mixed with lactide in a molar ratio of 1:20, polymerized at 160°C for 48 hours to obtain polylactic acid, which was pulverized below 0°C into polylactic acid powder. At low temperature, mix the powder and BMP evenly at a ratio of 100:1, press it into a certain shape below 38°C, and implant it into the bone defect site. After three weeks, the bone formation is obvious, and the surrounding tissues have no inflammation. After 12 weeks, the X-ray photos and Hard tissue sections showed good osteogenesis.

Embodiment 3

[0015] Example 3: Glycerin and lactide were mixed at a molar ratio of 1:10, polymerized at 180°C for 36 hours to obtain polylactic acid, which was pulverized below 0°C into polylactic acid powder. At low temperature, mix the polylactic acid powder and BMP evenly at a ratio of 1000:2, press it into a certain shape below 38°C, and implant it into the bone defect site. After three weeks, the bone formation is obvious, and the surrounding tissue is basically free of inflammation. After 12 weeks, X-ray photos and hard tissue sections showed that the osteogenesis effect was good.

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PUM

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Abstract

The invention discloses a preparation method of a highly active bone defect repairing material. The method is as follows: select polylactic acid (PLA), and mix bone morphogenic protein (BMP) and polylactic acid powder by 0.2%-2% (weight) at low temperature The ratio is mixed evenly; the above mixture is heated to below 38°C, and pressed into a bone defect repair material of the required shape. The advantages of the present invention are: the BMP / PLA complex prepared at low temperature is implanted into the living body, which can achieve the purpose of slowly releasing BMP and promoting bone tissue repair, has good biocompatibility, and effectively avoids solvents, high temperature, etc. The effect on the biological activity of BMP can effectively maintain the biological activity of BMP, and the effect of inducing osteogenesis is remarkable. It can be used for bone defect repair and has broad clinical application prospects.

Description

1. Technical field [0001] The invention relates to a preparation method of a medical biomaterial, in particular to a preparation method of a highly active bone defect repair material, and the prepared material can be applied to the repair of bone defects in a body. 2. Background technology [0002] Polylactic acid (PLA) is an excellent medical polymer material that can be degraded and absorbed in the body. It can be gradually decomposed into lactic acid in the body, and then metabolized by the human body to generate carbon dioxide and water to be excreted from the body without remaining in the human body. PLA itself is non-toxic, non-irritating and non-sensitizing to the human body, and it is easy to process. It has been widely used in medicine as a medical biomaterial, such as making absorbable surgical sutures, bone plates and screws, vascular staplers and Controlled release drug carrier, etc. [0003] Bone defects often occur after various traumas and tumor resections, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61P19/08
Inventor 胡勤刚沈健童昕陈强黄相道林思聪寿卫东喻春红
Owner 南京大学医学院附属口腔医院
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