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Method for producing conjugation linoleic acid

A technique of conjugated linoleic acid and its manufacturing method, which is applied in the fields of carboxylate preparation, chemical instruments and methods, fatty acid preparation/refining, etc., and can solve problems such as large consumption of raw materials, complex process flow, and unfavorable industrial production, and achieve The effect of saving raw material consumption and reducing production costs

Inactive Publication Date: 2005-06-15
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process of this method is complicated, and the consumption of raw materials is large, which is not conducive to industrial production.

Method used

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  • Method for producing conjugation linoleic acid

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Experimental program
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Effect test

Embodiment 1

[0016] Weigh 100g of safflower seed oil, pour it into an autoclave, add 200g of water, weigh 30g of NaOH, add it to the autoclave, then fill it with nitrogen to empty the air in the autoclave, close the system, and fill it with nitrogen until The pressure of the pressure gauge is 1.5Mpa, turn on the stirrer to stir, the stirrer speed is 100 rpm; raise the temperature to 180°C, react at a constant temperature for 5h, the reaction is over, under the protection of nitrogen, continue to stir, after the reaction mixture is cooled to room temperature, Add HCl for neutralization, adjust the pH value to 3, transfer the reaction mixture to a separatory funnel, extract with petroleum ether, and repeatedly wash with distilled water for 3 times, and distill the petroleum ether extract with a circular vacuum to finally obtain 73.5% of the Conjugated Linoleic Acid 90g.

Embodiment 2

[0018] Weigh 100g of safflower seed oil, pour it into an autoclave, add 500g of water, weigh 35g of NaOH, add it to the autoclave, then fill it with nitrogen and empty the air in the autoclave, close the system, and fill it with nitrogen until The pressure of the pressure gauge is 1.5Mpa, and the stirrer is turned on for stirring. The stirrer speed is 100 rpm; the temperature is raised to 210°C, and the reaction is carried out at a constant temperature for 2 hours. Add HCl for neutralization, adjust the pH value to 3, transfer the reaction mixture to a separatory funnel, extract with petroleum ether, and repeatedly wash with distilled water for 3 times, and distill the petroleum ether extract with a circular vacuum to finally obtain 74.8% of the Conjugated Linoleic Acid 89g.

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Abstract

The invention relates to a method for producing conjugated linoleic acid, which uses safflower seed oil containing more than 75% linoleic acid as a raw material, is characterized in that water is used as a solvent, and is carried out according to the following steps: Put the seed oil in the autoclave, add a certain amount of water and sodium hydroxide, fill the inert gas nitrogen to empty the air in the autoclave, close the system, and then fill the nitrogen until the pressure of the pressure gauge is 1.5Mpa, stir, Raise the temperature to 180-210°C and let it react for 2-5 hours. After the reaction is over, under the protection of nitrogen, continue to stir. After cooling to room temperature, add HCl for neutralization, adjust the pH value to 3, and transfer the reaction mixture to a separatory funnel , extracted with petroleum ether, and then vacuum distilled to obtain the product conjugated linoleic acid. The invention is characterized by using water as a solvent, which can save raw materials and reduce production costs.

Description

technical field [0001] The invention relates to a method for manufacturing conjugated linoleic acid, which belongs to the field of chemical product manufacturing. Background technique [0002] The essence of conjugated linoleic acid is the general term for various positions and spatial isomers of essential fatty acids—conjugated dienes derived from linoleic acid. In general, conjugated linoleic acid can be considered as a derivative of c9, c12-18:2 (LA). Scientists have found that conjugated linoleic acid has many important physiological functions: anti-cancer effect, anti-atherosclerosis, participates in fat decomposition and metabolism, enhances the body's immunity, promotes bone tissue metabolism, etc. The natural content of conjugated linoleic acid is very low, and artificial synthesis must be its largest source. [0003] The traditional synthesis method of conjugated linoleic acid is to use a large amount of high-boiling point solvents such as ethylene glycol, glycero...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/353C11C1/02
Inventor 翁新楚吴侯侯建平李坤
Owner SHANGHAI UNIV