Sustained releasing huperzine preparation

A slow-release preparation, huperzine A technology, applied in the direction of pill delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the impact of drug efficacy, patients can not remember the time of taking the medicine, and it is difficult to It is difficult to grasp the time and frequency of taking medicine to achieve the effect of feasible and reliable drug treatment

Inactive Publication Date: 2005-06-29
解健博
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For Alzheimer's patients with cognitive impairment and memory loss, it can be difficult to know when and how often to take medication
Some patients forget whether they have taken the medicine, some patients can't remember the time of taking the medicine, and some patients can't take it according to the requirements of the doctor and the medicine.
As a result, the efficacy of the drug is affected, thereby affecting the patient's recovery and treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Huperzine water-soluble matrix sustained-release tablet with a single tablet weight of 300 mg.

[0014] Component weight percentage: drug Huperzine A 0.1-0.4, speed control part uses hydroxypropyl methylcellulose 15, excipients use micronized silica gel 0.5, magnesium stearate 0.5, microcrystalline cellulose 30.0 and lactose 53.9- 53.6, a total of 100.0%.

[0015] The specific steps are as follows: Weigh each component according to the above prescription. Take Huperzine A, mix with microcrystalline cellulose for 10 minutes, add hydroxypropyl methylcellulose, lactose and micronized silica gel for another 10 minutes, add magnesium stearate and mix for 5 minutes. Transfer the mixed pellets to the feed hopper of the tablet machine, and adjust the tablet weight regulator to make the tablet weight about 300 mg. Take 500 grams of the tablet, transfer it to a small coating machine, and coat it with a 10% coating powder solution, and stop when the tablet weight increases ...

Embodiment 2

[0016] Example 2: Huperzine B matrix sustained-release tablet with a single tablet weight of 300 mg.

[0017] Component weight percentage: drug Huperzine B 0.1-0.4, 0.25 can be used, hydroxypropyl methylcellulose 20 is used for the speed control part, micronized silica gel 0.5, magnesium stearate 0.5, and microcrystalline cellulose 30.0 are used as excipients And lactose 51.1%-50.8, a total of 100.0%.

[0018] The specific steps are as "Example 1"

Embodiment 3

[0019] Example 3: Melaleuca tower extract matrix sustained-release tablet with a single tablet weight of 300 mg.

[0020] Component weight percentage: Melaleuca extract (Huperzia serrata) 1-4, 2.5 can be selected, hydroxypropyl cellulose 20.0 is used for the speed control part, micronized silica gel 0.5, magnesium stearate 0.5, lactose 70 -75, a total of 100.0%.

[0021] The specific steps are as "Example 1"

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A slowly releasing huperzine for treating sanile dementia by oral application features that its active components are huperzine A and its humolog, or their salts or ester derivatives. Its advantages are slow release (more than 12 hr), and high curative effect and safety.

Description

Technical field: [0001] The invention relates to an oral sustained-release and controlled-release pharmaceutical preparation, in particular to an oral sustained-release preparation of Huperzine A. Background technique: [0002] Alzheimer's disease is one of the most common senile diseases. Alzheimer's Disease (Alzheimer's Disease) is the most common type of Alzheimer's disease. Its pathogenesis is still under research. In short, the area of ​​the patient's brain responsible for controlling memory and reasoning has diseased, leading to brain function The gradual decline. Another more common type of Alzheimer's disease is vascular dementia, which is more common in the north. In addition to the above two types, there is another type called mixed dementia. [0003] With the emergence of the problem of aging population in our country, the prevention and treatment of Alzheimer's disease valve has become more and more important. [0004] Although many pathological studies have made some...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/132A61K31/44A61K47/12A61K47/14A61K47/36A61K47/44A61P25/28
Inventor 解健博
Owner 解健博
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap