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Use of mannan peptide in preparation of immunologic enhancement medication which is topically and orally applicated

A technology of mannan peptide and topical administration, which is applied in the field of application of mannan peptide in the preparation of immune-enhancing drugs for local administration in the oral cavity, and can solve the problems of large oral dosage and complex ingredients

Inactive Publication Date: 2006-05-24
成都利尔药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent 98121898 discloses "a kind of compound mannan peptide oral liquid", which contains multiple components, and its mannan peptides are from basidiomycete fungi, Septobasidiomycetes fungi, Polyporacea fungi, and Umbelliferae fungi. complex, large oral dose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] The preparation of example 1 mannan peptide:

[0022] Fermentation process: i, the preparation of bacterial classification: select bacterial classification to be α-hemolytic streptococcus (Streptococcushemolyticus-α-hemolysis);

[0023] Medium: Strain culture medium: glucose 0.4-0.8%, sodium chloride 0.4-0.8%, peptone 0.4-1%, beef extract 0.1-0.5%, sheep blood 10%, agar 1.5-2%, PH7.2- 7.8

[0024] Fermentation medium: glucose 0.1-0.5%, peptone 0.4-0.7%, yeast extract 0.4-0.6%, sodium chloride 0.4-0.8%, foam enemy 0.01%

[0025] Raw and auxiliary materials required for extraction and refining processes: alcohol, acetone, trichloroacetic acid, absolute ethanol

[0026] a. Mother bottle preparation: Unseal the strain freezing tube, dilute it with sterile broth medium, and insert it into the blood slant under aseptic conditions. 18-45 ℃ constant temperature culture for 24h;

[0027] b. Sub-bottle preparation: put the cultured blood slant strains into the broth culture m...

example 2

[0039] The preparation of example 2 pharmaceutical compositions of the present invention

[0040] Prepare the mannan peptide into a 50 mg / ml medicinal liquid slurry, granulate it with auxiliary materials through a fluidized bed, spray the granules with citric acid, lemon yellow pigment and essence, granulate, add magnesium stearate to the granules, mix evenly, compress into tablets, and make Into 1000 pieces, that is.

example 3

[0041] Example 3 Assay

[0042] Preparation of reference solution: Take about 0.1 g of D-mannose reference substance dried at 105°C to constant weight, weigh it accurately, put it in a 100ml measuring bottle, add water to dissolve and dilute to the mark, shake well, accurately measure 2ml, place Put it in a 100ml measuring bottle, add water to dilute to the mark, shake well, and you get it.

[0043]The preparation of need testing solution: get 20 pharmaceutical tablets of the present invention prepared by example 1, grind finely, accurately weigh, accurately weigh (equivalent to mannan peptide 25mg approximately), put in 25ml volumetric flask, add and cool to Dissolve in 20ml of water below 5°C, shake for 10 minutes, let it cool to room temperature, add water to the mark, shake well, immediately take 10ml (3000r / min) and centrifuge for 10 minutes, collect 2.5ml of supernatant and put it in a 100ml volumetric flask, add water Dilute to the mark, and prepare a solution containi...

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PUM

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Abstract

The invention provides the use of the mannan peptide in the preparation of an immune-enhancing drug for local administration in the oral cavity. Specifically, it relates to the use of mannan peptides in the preparation of medicines for oral local administration to treat recurrent respiratory tract infections and leukopenia. Clinical trials have proved that it is convenient and safe to take; it has significant advantages in the treatment of recurrent respiratory infections, chronic pharyngitis, aphthous sores and other local treatments. way of medication.

Description

technical field [0001] The invention provides a new application of the mannan peptide, in particular, the application of the mannan peptide in the preparation of an immune-enhancing drug for local administration in the oral cavity. Background technique [0002] As the environment changes, the incidence of human tumors continues to increase, and the age of onset is also lower than in the past. Finding safe and effective anti-tumor drugs is the goal that human beings have been working hard for. [0003] Tumor treatment through the body's defense mechanism was advocated by the National Cancer Institute of the United States in the late 1970s, and gradually developed worldwide in the 1980s. Japan is at the forefront in the research and development of immune activators against tumors, and has been approved for production and marketing. Streptococcus preparations of hemolytic streptococci (OK-432) were launched in 1975, and fungal polysaccharide preparations...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A61K9/20A61K9/70A61K9/12A61P37/04A61P11/00A61P7/00C12P21/00
Inventor 陈云华李军刘艳
Owner 成都利尔药业有限公司
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