VEGI, an inhibitor of angiogenesis and tumor growth
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- HUMAN GENOME SCI INC
- Publication Date
- 2001-02-28
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Background of the invention:
[0001] In very limited circumstances, a human or animal under normal physiological conditions undergoes angiogenesis, the creation of new blood vessels in a tissue or organ. For example, angiogenesis is commonly seen in wound healing, embryonic development and formation of the corpus luteum, endometrium and placenta. The term "endothelium" refers to a thin layer of squamous epithelial cells lining the serous cavities, lymphatics, and blood vessels. The term "anti-angiogenic" or "angiogenesis inhibitory activity" refers to the ability of a molecule to inhibit angiogenesis in general.
[0002] Controlled and uncontrolled angiogenesis are thought to proceed in a similar manner. Endothelial and mesenchymal cells surrounded by a basement membrane form capillaries. Angiogenesis begins with the erosion of the basement membrane by enzymes released by endothelial cells and leukocytes. Endothelial cells located within the lumen of the vessel then protrud...