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Yuquan extractum and its medicine composition and use

A technology of extract and Yuquan, which is applied in the direction of drug combination, drug delivery, and medical formula, can solve the problems of incomplete drug absorption, low bioavailability, and large dosage, and achieve easy storage and storage, high bioavailability, The effect of convenience

Active Publication Date: 2007-04-25
ZHEJIANG HISUN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has the disadvantages of low bioavailability, incomplete drug absorption, large dosage and thick, large, black appearance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Research on the extraction process of Yuquan extract

[0029] 1.1 Study on the extraction process conditions of Pueraria lobata, Schisandra, Licorice, Trichosanthes, Rehmannia glutinosa and Ophiopogon japonicus:

[0030] Due to the effective ingredient puerarin in Pueraria lobata, the A and B in Schisandra are more soluble in ethanol, and the polysaccharides in Ophiopogon japonicus, Trichosanthes, Rehmannia glutinosa, and glycyrrhizic acid in licorice are all water-soluble. In order to maximize the use of the effective ingredients of each medicine, we considered the first two to be extracted with high-concentration alcohol, and the rest was decocted in water, and eight processes were designed. details as follows:

[0031] Process 1: All six herbs are decocted in water, the first time is 10 times the amount, 1 hour; the second time, 8 times the amount, 1 hour.

[0032] Process 2: All 30% alcohol extraction (V / V), the first time is 10 times the amount, 1 hour; the ...

experiment example 2

[0105] Experimental example 2. Preparation method of Yuquan extract

[0106] Take 17 kilograms of Pueraria lobata, Schisandra, and Trichosanthes powder each, 17 kilograms of Rehmannia glutinosa and cut into pieces, 5.7 kilograms of licorice crushed into coarse powder, and 17 kilograms of Ophiopogon japonicus root tuber, and put Pueraria lobata root and schisandra into the extraction tank according to the final process. % Ethanol (V / V) 6 times the amount (272L), heated and refluxed for extraction for three hours, after releasing the extract, the same amount of 70% ethanol (V / V) was added again, and heated and refluxed for extraction for two hours. After the dregs of medicine are evaporated to dryness of ethanol, other medicinal materials are added together, and 10 times the amount of water is added respectively, and the extraction is carried out twice for one hour.

[0107] Combine the ethanol extract and the water extract, reduce pressure, and concentrate to a solid content of abo...

experiment example 3

[0108] Experimental Example 3. Preparation of Yuquan Extract

[0109] Take 17 kilograms of Pueraria lobata, Schisandra, and Trichosanthes powder each, 17 kilograms of Rehmannia glutinosa and cut into pieces, 5.7 kilograms of licorice crushed into coarse powder, and 17 kilograms of Ophiopogon japonicus root tuber. Put Pueraria lobata root and schisandra into the extraction tank according to the final process. % Ethanol (V / V) 8 times (272L), heated and refluxed for extraction for two hours, after releasing the extract, the same amount of 80% ethanol (V / V) was added again, and heated and refluxed for extraction for two hours. After the dregs were evaporated to dry the ethanol, the other medicinal materials were put in together, and 8 times 725.6L of water was added respectively, and the extraction was carried out for two hours for a total of two times.

[0110] Combine the ethanol extract and the water extract, reduce pressure, and concentrate to a solid content of about 16% (W / W). T...

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PUM

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Abstract

The present invention relates to a kind of diabetes treating Yuquan extractum, its preparation process and use, and the medicine composition containing the extractum. The extractum is prepared through heating and reflux extracting kudzu vine root and schisandra with alcohol; decocting the extracted residue together with trichosanthes root, ophiopogon root, licorice and rehmannia root and filtering; decompression concentrating the alcohol extract and water extract; and spray drying to obtain dried extractum. The Yuquan extractum in effective treating amount and medicinal supplementary material is prepared into diabetes treating medicine composition, which may be prepared into various kinds of forms, tablet, capsule, granule, etc. The Yuquan extractum and the medicine composition has fast acting, high bioavailability, less taken amount, high curative effect and other advantages.

Description

Invention field [0001] The present invention relates to a traditional Chinese medicine extract for the treatment of diabetes and a pharmaceutical composition and application thereof. Specifically, the present invention relates to a Yuquan dry extract for the treatment of diabetes and a pharmaceutical composition and application thereof. Background technique [0002] Diabetes is a common and frequently-occurring disease in the Department of Endocrinology. It is also known as adult-onset diabetes. It usually develops after the age of 35 to 40, accounting for more than 90% of diabetic patients. In recent years, it has gradually increased. Hyperglycemia is the main clinical sign, and chronic illness can cause damage to multiple systems throughout the body. It has the characteristics of refractory cure, high recurrence rate, lifelong medication, many complications, and high mortality rate. [0003] Commonly used western medicines for lowering blood sugar cannot provide comprehensive t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K36/804A61K36/57A61K36/484A61K36/48A61K36/428A61K9/00A61P3/10
Inventor 杨义芳乔艳红
Owner ZHEJIANG HISUN PHARMA CO LTD