Magnetically responsive composition
A technology of composition and biologically active substances, applied in the field of magnetic response composition, can solve problems such as large amount of energy, complex method of iron-carbon particles, etc.
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Embodiment 1
[0061] Tests were performed with Wistar Line male rats (raised at the Stolbovaya Station of the USSR Academy of Medical Sciences). Carcinosarcoma Walker 256 was instilled under the skin of the tail of rats. When the average tumor volume is 986±98mm 3 , the rats were divided into 4 groups, 10 in each group. The first group (group I) is the control group and groups II-IV are the experimental groups.
[0062] During a period of 5 days, rats of group II were injected intravenously with an aqueous solution of rubomicine (rubomicine) at 2 mg / kg body weight (the model in which this anticancer agent is used according to clinical tradition). Group III rats were injected with a suspension of iron-carbon dispersant prepared by methods known in the art described in European Patent Publication No. 0451299 A1. The particles contained iron / carbon in a volume percentage of 60:40. The dose of iron carbon particles is 160mg / kg body weight, and the dose of rubomicine adsorbed on it is 3.2mg / ...
Embodiment 2
[0068] Further clinical observations have confirmed the effectiveness of the present invention. Accompanying drawing 4 and 5 have illustrated and used composition of the present invention to live in Zil Hospital inMoscow on February 13th, 1992, Russia (CIS) (Zil hospital in Moscow, Russia), and be diagnosed with left breast cancer T 3 N 1 m 1 A 61-year-old woman underwent treatment and observed the results.
[0069] In 1989, the first diagnosis was made by taking a biopsy. In December 1991, local radiation therapy (10 Gy) partially reduced the tumor. It was decided to perform chemotherapy with intraarterial selective localization of the carrier of the invention on which Adriamycin was adsorbed as a bioactive agent.
[0070] Before treatment, the size of the tumor (shown in Figures 3A and 3B) was 44 mm x 33 mm x 37 mm (65 mm x 45 mm, manually). On February 24, 1992, the femoral artery (Fig. 4) was punctured under local anesthesia (0.5% novocaine, 30 ml), and the vascular c...
Embodiment 3
[0077] Recently, a series of screen-guided organ imaging experiments were performed in a porcine animal model using radioactive technetium (Tc) adsorbed on the carrier particles of the present invention as a contrast agent. To evaluate the physicochemical properties and interactions of Tc with carbon (C) and iron:carbon support particles, rhenium (Re) was used as a non-radioactive surrogate for Tc. In the periodic table, Re is a group VIIIB element just below Tc. Re has two artificial isotopes, 186 Re and 188 Re, as shown in Table 1 below, both have a longer half-life than Tc and emit about the same gamma rays.
[0078] isotope source
[0079] The colorimetric Re analysis used in the field of metallurgy was adapted to measure the adsorption of Re on support particles with an iron:carbon ratio of 70:30. Briefly, 0.1-0.5 ml of sample was placed in a solution containing 1.0 ml of HCl, 1.3 ml of furildioxime (60% in acetone), 0.5 ml of 10% stannous chloride, and suffi...
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