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Process and composition for cleaning medical instruments

A technology for medical devices and compositions, applied in cleaning methods and utensils, cleaning methods using liquids, detergent compositions, etc., can solve problems such as waste of disinfectants, infection of staff, skin penetration of gloves, etc.

Inactive Publication Date: 2003-06-04
NOVAPHARM RES AUSTRALIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The worker is therefore at risk of infection (i) from scrubbing to release contamination or from splashes from the first dip (or spills from an instrument accidentally dropped into the dip) when the first dip is poured, (ii) ) from breakage in the glove (latex gloves have about 12% "pinhole" damage), (iii) from accidental dipping of the glove above the wrist line, (iv) from incidents of pricking fingers in the dip, causing the glove to even Sometimes skin penetration, (v) from brushing and aerosol from injection
In addition, the wall surface of the first immersion liquid is still contaminated after the immersion liquid is poured out, and if it is not self-sterilized, it will be handled by unprotected staff
The last-mentioned hazard can be minimized by performing a disinfection step immediately after the digestion step in the same vessel, but this does not avoid other currently unrecognized hazards, and the use of excess sanitizer is wasteful

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 is a composition which is a storage stable concentrate but diluted with water to a ratio of 200:1 to 1000:1 (ie 200 or 1000 parts / wt water to 1 part / wt concentrate) for use. Compositions are used to compare the effects of adding various ingredients to quaternary ammonium antibiotics.

[0045] g / 1

Benzyldimethylammonium chloride, CAS 68424-85-1

150

Sodium tetraborate decahydrate, CAS 12007-42-0

30

Glycerin, CAS 56-81-5

25

Terric GN9 (Note 1)

200

Dipropylene glycol methyl ether CAS 34590-94-8

100

water balance to

1000

[0046] Note 1: Terric GN9 is ethoxylated nonylphenol purchased from ORICA, which is a nonionic surfactant.

[0047] Preparation: Sodium tetraborate is dissolved / suspended in glycerol at 80°C. Quaternary ammonium antibiotics and Terric GN9 (non-ionic disinfectant) are mixed with DPM and the pH is adjusted to pH 7.2-7.3 with eg acetic acid. The boric acid / glycerol...

Embodiment 2

[0049] Example 2 is the same as Example 1 but contains 0.1% subtilisin (0.1% protease).

[0050] Table 1 shows the MIC results obtained for various combinations of the ingredients of Example 1 and Example 2 in the absence of boron and, according to the invention, in the presence of boron. "Quat" in Table 1 is an abbreviation for benzyldimethylammonium chloride.

[0051] combination

MIC, ppm

(boron-free)

MIC, ppm

(contains boron)

A

1.quat (existing technology)

20

12

2.quat+DPM

16

8

3.quat+GN9

25

8

4.quat+DPM+GN9

16

＜8

B

1 quat + subtilisin

(0.1% protease)

50

25

2 quat+DPM+enzyme

25

12

3 quat+GN9+enzyme

25

12

4 quat+dpm+GN9+enzyme

25

8

[0052] Part A of Table 1 compares the MIC of various quaternary ammonium antibiotic compositions in the absence of boron and in the presence of b...

Embodiment 3

[0056] Example 3 shows a preferred example of the present invention. The composition of Example 3 is a concentrate and will be diluted at a ratio of 1 part / wt to 200 parts / wt water. The compositions are to be used as pre-dips for surgical instruments.

[0057] Element

%w / w

A.

Ethoxylated Nonylphenol (Terric GN9)

3

Bis(propylene glycol) methyl ether

5

fragrance

0.1

water

15

B.

Sodium tetraborate decahydrate

6

Glycerin

4

water

5

C.

Acetic acid to pH7.2-7.3

D.

Ethylene glycol

5

(10% Subtilisin) Alcalase 2.5DL

3

E.

Benzalkonium Chloride 80%

30

water

to 100

[0058] Premix borax with hot water and glycerin, add to A, adjust pH, allow mixture to cool to 30°C, then slowly add premixed ingredient D. Water premixed 80% with benzalkonium chloride was then added.

[0059] When stored in...

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PUM

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Abstract

The invention relates to a method for cleaning a contaminated medical instrument including the step of immersing the instrument in a solution containing an enzyme based cleaning composition including a ''hospital grade disinfectant''. Compositions useful for cleaning contaminated medical instruments in accordance with the method include an enzyme, a quat biocide and an ''activity protector'', which may be for example, enzyme stabilizers, enzyme stabilizing systems, micelle formation modifiers and inhibitors, and combinations thereof.

Description

field of invention [0001] The present invention relates to a method and composition for cleaning medical instruments. The method is applicable to endoscopy, and is specifically referred to for that use herein, but it is understood that the method is equally applicable to other instruments, such as colonoscopes, laparoscopes, other surgical, medical, biopsy, dental, etc. instruments whose Components and similar devices (hereinafter collectively referred to as "medical devices"). The invention can also be used to treat instruments that only need to be sterilized, such as hairdressing tools, some beauty salon equipment, and the like. Background technique [0002] Endoscopes are used more and more in medical diagnosis and treatment. When used as a guide, the endoscope is completely soiled and heavily infected with microorganisms present in body cavities, mucosal surfaces and blood. Instruments must therefore be adequately cleaned and disinfected after each use. Endoscope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B08B3/08A01N33/12A01N63/00A61B1/12A61L2/18C11D1/62C11D3/04C11D3/20C11D3/26C11D3/34C11D3/36C11D3/386C11D3/39C11D3/48C11D17/08
CPCA61L2/18C11D1/62C11D3/38645A01N33/12C11D11/0041C11D3/48C11D3/38618C11D3/38627A61L2202/24C11D3/38636C11D2111/20A01N2300/00A01N63/50A01N37/46A01N25/30A01N25/22
Inventor A·萨瓦S·克里兹尔
Owner NOVAPHARM RES AUSTRALIA