Oral cavity adhesive plaster composition for curing gingival disease, laryngopharyngitis and halitosis

A composition and technology for pharyngitis, applied in the direction of drug combination, tablet delivery, respiratory diseases, etc., can solve the problem of not being able to maintain a long enough antibacterial effective time in the oral cavity, and achieve simple preparation, convenient use, and periodontal treatment The effect of inflammation

Inactive Publication Date: 2003-09-24
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved in the present invention is to disclose a kind of oral paste composition for the treatment of gum disease, pharyngitis and halitosis, so as to overcome the defects in the prior art that the antibacterial effective time cannot be maintained in the oral cavity for a long enough time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Each tablet weighs 200mg, and the formula is as follows:

[0021] Chlorhexidine 5mg

[0022] Carbopol 60mg

[0023] Cyclodextrin 72mg

[0024] Dipeptide sugar 1.3mg

[0025] Dextrin 60mg

[0026] Eucalyptus Peppermint Oil 0.70mg.

[0027] Magnesium stearate 1.0mg Coat eucalyptus mint oil with cyclodextrin, mix it evenly with the other above-mentioned materials, add magnesium stearate after wet granulation, and press into tablets with a 10mm punch to obtain the product. Each tablet contains 5mg of chlorhexidine.

Embodiment 2

[0029] Each tablet weighs 200mg, and the formula is as follows:

[0030] Dumephen 0.5mg

[0031] Hypromellose 120mg

[0032] Dipeptide sugar 2.5mg

[0033] Dextrin 70mg

[0034] Talc powder 7.0mg

[0035] After mixing the above materials evenly, dry granulate, add talcum powder, press with a 10mm punch, and each tablet contains 0.5mg of the main drug.

Embodiment 3

[0037] In vitro drug release of chlorhexidine oral adhesive tablet:

[0038] Release time (h)

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PUM

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Abstract

The present invention discloses an oral adhesive plaster composition for curing gingivitis, laryngopharyngitis and halitosis. The described oral adhesive plaster composition includes water-soluble polymer adhesive matrix with adhered effective dose, bacteria-killing disinfectant with bacteria-killing effective dose and medicinal acceptable excipient. Said composition can be adhered in oral cavity, generally it is plastered on the mandibula, after having been plastered, the medicine table surface can be slowly dissolved, at the same time the medicine can be released, and retained in oral cavity for a relatively-long period of time (greater than 2 hr.) so as to obtain the goal of cleaning oral cavity, curing periodontitis, chronic pharyngitis and eliminating halitosis.

Description

technical field [0001] The invention relates to a medicament for treating oral diseases, in particular to an oral patch composition for treating gum disease, pharyngitis and bad breath. Background technique [0002] Traditionally, the radical cure of gum disease often chooses surgery, but in recent years, various antibiotics have been used to successfully treat the disease caused by this bacterium. Compared with surgical treatment, drug treatment is painless and convenient. Many people have gum disease (approximately 50-70% of people over the age of 35), which is a bacterial infection of the gum tissue caused by plaque formation, of which approximately 30% develop due to the spread of bacteria from the gums into the bone into periodontitis. [0003] The throat is one of the important trachea of ​​the human body. Many colds and colds also start from pharyngitis. Improper treatment of pharyngitis can easily lead to infections such as streptococcus, staphylococcus, and pneum...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/138A61K31/155A61K31/7048A61K47/30A61K47/36A61P1/02A61P11/04
Inventor 贺芬侯惠民
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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