Application of scutellarin composition in preparing medicine for preventing and treating diabetes complication
A technology of breviscapine and a composition, which is applied to the application field of the breviscapine composition in the preparation of medicines for preventing and treating diabetes complications, can solve the problems of elevated blood pressure, no definite curative effect, etc., and achieves vision improvement, rapid effect, and improvement The effect of fundus blood flow velocity
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Embodiment 1
[0020] Astragalus is extracted by water-alcohol method: take the medicinal material and add 95% ethanol to heat and reflux twice. For the first time, use 8 times the amount of crude drug weight of ethanol for reflux for 1 hour, for the second time 6 times the amount for reflux for 1 hour, filter, and discard the filtrate. Add water to decoct the dregs respectively, filter or continue to add ethanol to precipitate, filter, concentrate the filtrate, and dry in vacuum. Salvia miltiorrhiza is extracted by supercritical fluid extraction (pressure: 20Mpa, temperature: 34°C, CO 2 Flow: 5L·min -1 , extraction time: 3h). 1 part of breviscapine, 0.8 parts of astragalus extract, and 0.3 parts of salvia miltiorrhiza extract. Mix breviscapine with astragalus extract and danshen extract, dissolve with PEG4000, and make drop pills.
Embodiment 2
[0022] Using the whole plant of Eeigeron breviscapus (VantHand-Mazz) of the genus Asteraceae, according to the current conventional extraction method of breviscapus, such as extraction with 75% ethanol, the extract is evaporated to ethanol, concentrated, and the pH is adjusted with NaOH to 6.5 Dissolved, filtered, and the filtrate was washed with H 2 SO 4 Adjust the pH to 2.0, separate out breviscapine, and refine to obtain 100 grams of 4', 5, 6-trihydroxyflavone-7-O-glucuronide (breviscapine) extracted. Extract 80 grams of the extract by alcohol precipitation, add starch and dextrin according to the existing method of those skilled in the art, mix and granulate to make granules.
Embodiment 3
[0024] Get 100 grams of breviscapine, mix with 20 grams of the water-extracted and alcohol-precipitated extract of Radix Astragali extracted by the method of Example 1, and 100 grams of the extract of Salvia Miltiorrhiza extracted by the extraction method of Example 1, mix with PEG 4000 The matrix is heated and dissolved, and the drop pills are prepared by a drop pill maker.
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