Application of scutellarin composition in preparing medicine for preventing and treating diabetes complication

A technology of breviscapine and a composition, which is applied to the application field of the breviscapine composition in the preparation of medicines for preventing and treating diabetes complications, can solve the problems of elevated blood pressure, no definite curative effect, etc., and achieves vision improvement, rapid effect, and improvement The effect of fundus blood flow velocity

Inactive Publication Date: 2003-10-22
朱邦豪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even ACEI (Angiotensin Converting Enzyme Inhibitor) has no positive effect on diabetic nephropathy comorbidity
Although the synthetic drug aminoguanidine has a certain effect on the preventi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1

[0020] Astragalus is extracted by hydroalcoholic method: take the medicinal materials and add 95% ethanol to heat and reflux for 2 times, use 8 times the weight of crude drug for the first time, reflux for 1 h, and 6 times for the second time, reflux for 1 h, filter, and discard the filtrate. The medicinal residue was decocted in water, filtered or continued to add ethanol for precipitation, filtered, the filtrate was concentrated, and vacuum dried. Salvia miltiorrhiza was extracted by supercritical fluid extraction (pressure: 20Mpa, temperature: 34℃, CO 2 Flow rate: 5L·min -1 , Extraction time: 3h). Taking 1 part of breviscapine, 0.8 part of astragalus extract, and 0.3 part of salvia miltiorrhiza extract, the breviscapine was mixed with the astragalus extract and the salvia miltiorrhiza extract and dissolved with PEG4000 to prepare dripping pills.

Example Embodiment

[0021] Example 2

[0022] Using the whole plant of Eeigeron breviscapus (VantHand-Mazz) of the genus Compositae, according to the current conventional extraction method of breviscapus, such as 75% ethanol extraction, the extract is evaporated from ethanol, concentrated, and the pH is adjusted with NaOH to 6.5 Dissolve, filter, use H for filtrate 2 SO 4 Adjust the pH to 2.0, precipitate scutellarin, and refine it to obtain 100 grams of 4',5,6-trihydroxyflavone-7-O-glucuronide (scutellarin). Astragalus is extracted with the water of Example 1. 80 grams of the extract is extracted by alcohol precipitation, and starch and dextrin are mixed and granulated according to the existing method of those skilled in the art to prepare granules.

Example Embodiment

[0023] Example 3

[0024] Take 100 grams of breviscapine and mix it with 20 grams of the water-extracted and alcohol-precipitated extract of Astragalus by the method of Example 1 and 100 grams of the extract of Salvia miltiorrhiza extracted by the method of Example 1 and mix with PEG 4000 To dissolve the substrate by heating, the dripping pill is prepared by a dripping pill maker.

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PUM

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Abstract

The present invention relates to Scutellarin, i.e. 4,5,6-trihydroxyflavone-7-O-glucuronic acid glucoside composition and its new application in preparation of medicine for preventing and curing diabetes complication. Said composition possesses the obvious therapeutic effect for curing diabetes nephropathy and diabetes ophthalmopathy complication.

Description

technical field [0001] The present invention relates to the application of the composition of breviscapine extract-4',5,6-trihydroxyflavone-7-O-glucuronide, namely breviscapine, in the preparation of drugs for preventing and treating diabetes complications. Background technique [0002] Erigeron breviscapus is the whole plant of Compositae, which has the effects of promoting blood circulation and removing stasis, regulating qi and relieving pain. Motherland medicine uses it to treat cerebrovascular diseases, and the curative effect is remarkable. Breviscapine is the active ingredient extracted from the breviscapine flower. It is now clinically used to treat cerebral insufficiency, cerebral thrombosis, sequelae caused by cerebral hemorrhage, and hyperviscosity. [0003] For the current treatment of diabetes, although there are many clinical drugs such as insulin that can effectively control the blood sugar level of diabetic patients, most diabetic patients die from related ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10
Inventor 朱邦豪
Owner 朱邦豪
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