Double-effect evaporating and crystallizing production process of low-solubility, easy-crystallizing and thermosensitive material

Abstract

The invention is a double effect evaporation crystal craft for low solubility, easy to crystal, temperature-sensitive material. Parts of the second vapor distilled by the first effect appliance and the heated vapor which is put in continuously are pressed by the heat pump and are transmitted into the shell pass of the first appliance to be used as the heat source, the remanant second vapor distilled b the first effect appliance and the condensate discharged by the first outward circulation evaporator is put in the second outward circulation evaporator shell pass, the distilled vapor are used as the heat source of the second effect outward evaporator. Because that the water of the first effect appliance is used fully, it decreases the quantity of the vapor and the loss of heat energy.

Description

technical field [0001] The invention relates to a low-solubility, easy-to-crystallization, heat-sensitive material evaporation crystallization production process, in particular to an improved low-solubility, easy-to-crystallization, heat-sensitive material double-effect evaporation crystallization production process. Background technique [0002] In the prior art, low solubility, easy crystallization, heat sensitive material solution is affected by its characteristic factors such as strong heat sensitivity, low concentration, and easy crystallization. High energy, large discharge of distilled water (steam), high discharge temperature of distilled water (steam) and condensed water, serious loss of heat energy, low utilization rate of heat energy, large consumption of cooling water for processing distilled water, high cost of environmental protection and prevention, has become a Bottlenecks restricting production, such as the production of L-phenylglyci...

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Problems solved by technology

[0002] In the prior art, low solubility, easy crystallization, heat sensitive material solution is affected by its characteristic factors such as strong heat sensitivity, low concentration, and easy crystallization. High energy, large discharge of distilled water (steam), high discharge temperature of distilled water (steam) and condensed water, serious loss of heat energy, low utilization rate of heat energy, large consumption of cooling water for processing distilled water, high cost of environmental protection and prevention, has become a Bottlenecks restricting production, such as the production of L-phenylglycine by evaporation and crystallization, L-phenylglycine, also known as D acid, is produced by biological fermentation and is mainly used as a raw material for semi-synthetic antibiotics such as amoxicillin and cephalosporins. It is an important pharmaceutical intermediate with a great market prospect, but the current production process is: first use biological fermentation to produce D-acid fermentation broth, and then use evaporation and crystallization equipment to evaporate the water in D-acid fermentation broth to crystallize D-acid Due to the unique temperature of D acid fermentation broth can not exceed 70 ℃, the concentration is about 2.5%, the solubility is about 3%, the amount of distilled water is large, and the evaporation process is accompanied by the appearance of a large number of crystals and the storage time should not be too long. Evaporation and crystallization production mostly adopts single-effect evaporation and crystallization equipment consisting of an external circulation evaporator, vapor-liquid separator, and clear liquid circulation pump. The single-effect evaporation and crystallization production process using such single-effect evaporation and crystallization equipment: Every 1 ton of D 28 tons of water will be distilled out of acid, and 1.1 to 1.5 tons of saturated steam will be consumed for every ton of water steamed, which is high energy consumption. In addition to the condensation of cooling water, the discharged water (steam) also takes away a large amount of heat energy, and the loss of heat energy is serious, which restricts the production of D acid

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