A anti-enveloped virus recombinant polypeptide and its preparation method

An antiviral and viral envelope technology, applied in antiviral agents, botanical equipment and methods, biochemical equipment and methods, etc., can solve the problems of expanding the application scope of colistin, achieve high targeting, reduce toxic side effects
CN1482242AInactive Publication Date: 2004-03-17CHENGDU PHOTON BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHENGDU PHOTON BIOTECH
Publication Date
2004-03-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to one kind of enveloped virus resisting polypeptide and its encoding nucleotide and amino acid sequence. Colicin capable of forming ion channel or its aquatic porous channel structural domain is made to combine with polypeptide capable of being combined specifically with target virus envelope antigen to form engineering polypeptide. Inside the engineering polypeptide, ScFv antigen combining area capable of being combined specifically with target virus envelope antigen induces the colicin water soluble porous channel structural domain to near target virus envelope, the colicin water soluble porous channel structural domain then forms the ion channel on the envelope to destroy the completeness of the envelope to leak or expose virus RNA and kill virosome. The antiviral engineering polypeptide kills selected virosome without injuring host cell, being superior to traditional antiviral medicines.
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Description

technical field

[0001] The present invention relates to a recombinant antiviral polypeptide, in particular to the anti-enveloped virus polypeptide, and the nucleotide and amino acid sequences encoding the polypeptide.

[0002] The invention also relates to the preparation method of the recombinant antiviral polypeptide. Background technique

[0003] Viral infection has become a major threat to human life and health. As the earth's biosphere is increasingly destroyed by human industrialization, viral diseases, such as viral hepatitis, influenza, pneumonia, encephalitis, tumors caused by viruses, and AIDS, are becoming more and more rampant. Because the genes of viruses are prone to mutations, the damage caused by viruses is often involved in the malfunction of the host immune system. The mechanism is still being explored, so people have been working hard to try to prepare truly effective antiviral drugs.

[0004] At present, antiviral treatment mainly starts from the followi...

Claims

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