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Hippophae rhamnoide flavone drops and preparation thereof

A technology of acetaloflavone and dripping method, which is applied in the direction of pill delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of affecting the therapeutic effect of acetaloflavone, large proportion of excipients, low bioavailability, etc. , to achieve the effect of convenient carrying and taking, reduced dosage of excipients and good compliance

Inactive Publication Date: 2004-04-21
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, only acetaloflavone tablets are sold in the market, which not only has a single dosage form, but also has a long disintegration time, poor absorption, low bioavailability, and a large proportion of auxiliary materials due to the fact that acetaloflavone tablets are insoluble in water and have strong hydrophobicity. , children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of aceflavone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] prescription:

[0022] Acetaloflavone 5g

[0023] Macrogol 6000 15g

[0024] Makes 1000 capsules

[0025] Preparation method: Take the fine powder of acetaloflavone that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry to obtain .

example 2

[0027] prescription:

[0028] Acetaloflavone 5g

[0029] Macrogol 4000 15g

[0030] Makes 1000 capsules

[0031] Preparation method: Take the fine powder of acetaloflavone that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, and obtain .

example 3

[0033] prescription:

[0034] Acetaloflavone 5g

[0035] Macrogol 6000 5g

[0036] Macrogol 4000 10g

[0037] Makes 1000 capsules

[0038] Preparation method: Take the fine powder of acetaloflavone that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone oil as a coolant, and drip The legal pills are dried and obtained immediately.

[0039] 4. Example 4

[0040] prescription:

[0041] Acetaloflavone 5g

[0042] Glyceryl monostearate 15g

[0043] Makes 1000 capsules

[0044] Preparation method: Take the acetaloflavone fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain.

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PUM

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Abstract

A dripping pill of acetylsalicylic flavone is prepared through superfine pulverizing and conventional steps for preparing dripping pill. Its advantages are high disintegration and dissolving speed, quickly taking its effect and low cost.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to acetaloflavone dropping pills and a preparation method thereof. Background technique [0002] Acetaloflavones can increase the blood flow of myocardium and brain tissue in experimental animals, reduce myocardial oxygen consumption, improve hypoxia tolerance; improve heart and brain ischemia and arrhythmia and cell damage caused by ischemia; reduce serum cholesterol and low density Increase the content of lipoprotein, increase the content of high-density lipoprotein; dilate blood vessels, lower blood pressure; inhibit platelet aggregation, reduce blood viscosity. [0003] Acetaloflavones are digested and absorbed through the gastrointestinal tract and excreted through the urethra. Currently on the market, only acetaloflavone tablets are clinically used as adjuvant therapy for coronary heart disease, hyperlipidemia and hypertension. [0004] Acetaloflavon...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/352A61P3/06A61P9/06A61P9/12
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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