Super saturated and soluble type skin administration medicinal composition substrate
A dissolving and matrix technology, applied in medical science, bandages, absorbent pads, etc., to achieve the effects of improving skin permeability, increasing effective utilization, and low cost
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Embodiment 1
[0015] In the existing pressure-sensitive adhesive preparations for percutaneous administration of estradiol, the concentration of estradiol in the pressure-sensitive adhesive is generally 1-2% by weight in the matrix content, mainly because of worrying about the crystallization of the drug in the pressure-sensitive adhesive. However, for preparations containing chemical accelerators in the matrix, the concentration of estradiol is generally below 1%. In this embodiment, a high concentration of 4% is used, and the most commonly used chemical accelerator is isopropyl myristate (IPM). Human skin allergy experiments show that 20% IPM will not have any adverse effects and sequelae on the skin.
[0016] Composition Weight %
[0017] Base Polyacrylate Pressure Sensitive Adhesive 66%
[0018] Estradiol 4%
[0019] Isopropyl myristate 20%
[0020] Crystallization Inhibitor 10%
[0021] Using the usual paste technique, the prepared matrix mother liquor is coated on the plastic fil...
Embodiment 2
[0025] Composition Weight %
[0026] Base Polyacrylate Pressure Sensitive Adhesive 44%
[0027] Prednisolone 4%
[0028] Oleic Acid 20%
[0029] Isopropyl myristate 20%
[0030] Crystallization Inhibitor 12%
Embodiment 3
[0032] Composition Weight %
[0033] Base Polyacrylate Pressure Sensitive Adhesive 76%
[0034] Melatonin 4%
[0035] Oleic acid (Polyethenosy oleyl alcohol 1) 10%
[0036] Crystallization Inhibitor 10%
[0037]
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