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Method for preparing capsule of six drugs containing rehmannine

A technology of capsule preparation and Liuwei Rehmannia glutinosa is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients. The effect of eliminating residual pesticides and heavy metal impurities, reducing drug dosage and improving drug efficacy

Inactive Publication Date: 2004-07-21
四川泰华堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The shortcoming of this capsule preparation method is: because a large amount of medical materials are directly pulverized into medicine, its pesticide residue, heavy metal impurity residue are higher, affect drug effect; The finished product takes 8 capsules once, and taking dosage is big, and each capsule active ingredient is relatively low, detrimental to patients

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  • Method for preparing capsule of six drugs containing rehmannine
  • Method for preparing capsule of six drugs containing rehmannine

Examples

Experimental program
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Effect test

Embodiment 1

[0020] [Prescription] Rehmannia glutinosa 1408g, peony bark 528g, yam 704g

[0021] Dogwood 704g Alisma 528g Poria 528g

[0022] [Preparation method] For the above six flavors, take 110g of Poria cocos and grind them into fine powder, sieve the remaining part and decoct the remaining Poria cocos with water for three times, 30 minutes each time, filter, combine the filtrate, concentrate to a thick paste; add ethanol to reflux and extract twice , 1 hour each time, filter, and the dregs are ready for use; the filtrate recovers ethanol and concentrates to a thick paste; Moutan cortex is steam distilled, and 1mol / L hydrochloric acid solution is added to the collected distillate to crystallize, filter, and crystallize with water Wash, dry at low temperature, grind into fine powder; distilled aqueous solution, Moutan cortex dregs, Cornus officinalis dregs, and other Rehmannia glutinosa, etc., add water and decoct three times, each time for 1 hour, filter, combine filtrates, and...

Embodiment 2

[0030] [Prescription] Rehmannia glutinosa 1408g, peony bark 528g, yam 704g

[0031] Dogwood 704g Alisma 528g Poria 528g

[0032] [Preparation method] Take the above six flavors, take 350g of Poria cocos and grind them into fine powder, add ethanol to reflux and extract twice, each time for 1 hour, filter, and use the dregs for later use, recover ethanol from the filtrate, concentrate to a thick paste; Moutan cortex is steam distilled , the distilled liquid is crystallized, and set aside; the distilled aqueous solution, Moutan bark dregs, Cornus officinalis dregs, remaining Poria cocos and the rest of Rehmannia glutinosa are decocted in water three times, each time for 1 hour, filtered, combined filtrates, and concentrated to a thick paste Add the above-mentioned Poria cocos fine powder and cornus officinalis thick ointment, mix well, dry at low temperature, grind into fine powder, add the above-mentioned Moutan Cortex extract and appropriate amount of auxiliary materials...

Embodiment 3

[0035] [Prescription] Rehmannia glutinosa 1408g, peony bark 528g, yam 704g

[0036] Dogwood 704g Alisma 528g Poria 528g

[0037] [Method] For the above six flavors, take 110g of Poria cocos and crush them into fine powder, sieve the remaining part and decoct the remaining Poria cocos with water three times for 30 minutes each time, filter, combine the filtrates, and concentrate to a thick paste; Cornus officinalis is percolated with ethanol, collected The percolation liquid and medicinal residues are used for later use; the ethanol is recovered from the filtrate and concentrated to a thick paste; the cortex of Moutan is steam distilled, and 1mol / L hydrochloric acid solution is added to the collected distillate to crystallize, filtered, and the crystals are washed with water and dried at low temperature. Grind into a fine powder; distilled aqueous solution, moutan cortex dregs, dogwood dregs, and the rest of Rehmannia glutinosa, etc., were decocted with water three times,...

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Abstract

A process for preparing the six-element Dihuang capsule includes pulverizing part of tuckahoe, decocting its rest to obtain extract, extracting from dogwood fruit and concentrating to obtain extract, distilling tree peony bark to obtain crystal, decocting the rehmannia root, yam, alismatis rhizome and other dregs, purifying, mixing all together, and loading in capsules. Its advantages are high curative effect and low dosage.

Description

technical field [0001] The invention relates to a preparation method of Liuwei Dihuang Capsules. Background technique [0002] The prescription of Liuwei Dihuang Wan first appeared in the Song Dynasty. It was made by Qian's Shenqi Wan in "Synopsis of the Golden Chamber" by Zhang Zhongjing, a medical sage of the Eastern Han Dynasty, and subtracted Fuzi, Guizhi, and Yigan Dihuang into Shudihuang. It is recorded in ancient documents that Liuwei Dihuang Wan is composed of Rehmannia glutinosa, Cornus officinalis, dried yam, Alisma, Moutan cortex, and Bai Fuling. Prescription Rehmannia glutinosa: sweet in taste, slightly warm in nature, has the functions of nourishing yin and blood, benefiting essence and filling marrow. Indications for liver and kidney yin deficiency, sore waist and knees, hot flashes, night sweats and nocturnal emission, internal heat and thirst, blood deficiency and chlorosis, palpitations, irregular menstruation, metrorrhagia, dizziness, tinnitus, premature g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P1/14
Inventor 俞凯
Owner 四川泰华堂制药有限公司