K-carrageenan oligosaccharide monomer and its preparation method

A carrageenan oligosaccharide and monomer technology, which is applied in the field of K-carrageenan oligosaccharide monomer and its preparation, can solve the problems of studying the action mechanism of K-carrageenan oligosaccharide, technical difficulty and unacceptable synthesis cost, and achieves Overcome the difficulty of desalination and improve the quality

Inactive Publication Date: 2004-07-21
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the current technology and patents for the degradation and preparation of carrageenan oligosaccharides, the mixture of oligosaccharides is obtained, which is not conducive to further in-depth research on the structure and activity of oligosaccharides, that is, the structure-activity relationship, and is not conducive to the study of K-carrageenan from the molecular level. The relationship between gum oligosaccharides and their derivatives and the occurrence and development of diseases and their mechanism of action can guide the r

Method used

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  • K-carrageenan oligosaccharide monomer and its preparation method
  • K-carrageenan oligosaccharide monomer and its preparation method
  • K-carrageenan oligosaccharide monomer and its preparation method

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Embodiment

[0016] Degrade K-carrageenan with 0.05-1.0M acid at 60-100°C for 20-180 minutes, neutralize it with alkali, concentrate by rotation, precipitate it with alcohol, wash it, and detect it with a differential detector at 0.05-0.5 Ammonium bicarbonate of M was used as the mobile phase, separated by a Superdex 30 column, collected according to the elution peaks, concentrated, and then freeze-dried to obtain the final product. A total of 10 carrageenan monomer oligosaccharides, their molecular weights are 1506, 1914, 2322, 2730, 3138, 3546, 3954, 4362, 4770 and 5178.

[0017] Wherein said acid is hydrochloric acid, sulfuric acid, nitric acid and oxalic acid; Alkali is sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate.

[0018] From figure 1 It can be seen that all odd-numbered K-carrageenan oligosaccharides with a degree of polymerization of 7-25 are well separated. From figure 2 It can be seen that each oligos...

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Abstract

A k-carragheenin oligose monomer C18+12nH28+17n O21+12nS2+nNa2+n, where n=2-11, is prepared from k-carragheenin through degrading by acid, neutralizing by alkali, concentrating, depositing in alcohol, washing and separating by superdex 30 column using the solution of ammonium hydrogen carbonate as flowing phase. Its advantages are simple process and high efficiency.

Description

technical field [0001] The invention relates to a K-carrageenan oligosaccharide, in particular to a K-carrageenan oligosaccharide monomer with a polymerization degree of 7-25 and a preparation method thereof. Background technique [0002] Carrageenan is the cell wall polysaccharide of certain red algae, which is a galactan sulfate ester composed of galactose and galactose derivatives, in which K-carrageenan is a 1,3-linked 4-sulfate group-β-D - Polymers of galactose linked alternately with 1,4-linked 3,6-endidether-α-D-galactose. Because carrageenan is a natural polyanionic sulfated polysaccharide, it is widely used in the fields of medicine, food, agriculture and daily chemical industry. In recent years, many important biological functions and physiological activities of carrageenan oligosaccharides and their derivatives have been gradually recognized by people, and they have shown good applications in antibacterial, antiviral, antitumor, anticoagulant and antiulcer, etc. ...

Claims

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Application Information

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IPC IPC(8): C08B37/00
Inventor 于广利赵峡王长云管华诗
Owner OCEAN UNIV OF CHINA
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