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Monolayer osmotic pump controlled releasing tablets of nimodipine

An osmotic pump controlled-release, dipine monolayer technology, applied in the field of medicine, can solve the problems of many times of taking medicines, inconvenient taking, large fluctuations in blood drug concentration, etc., and achieve the effects of stable curative effect, long-lasting effect, and small toxic and side effects.

Inactive Publication Date: 2004-12-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Commercially available nisoldipine ordinary tablets are taken frequently, which is inconvenient to take, and the blood concentration fluctuates greatly

Method used

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  • Monolayer osmotic pump controlled releasing tablets of nimodipine
  • Monolayer osmotic pump controlled releasing tablets of nimodipine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] This example was prepared using methods known in the pharmaceutical industry. The tablet contains the following ingredients by weight percentage:

[0018] Tablet composition:

[0019] Nisoldipine 2.9%

[0020] Polyoxyethylene (molecular weight: 300,000) 48.3%

[0021] Sodium chloride 48.3%

[0022] Magnesium Stearate 0.5%

[0023] 10% povidone K30 ethanol solution appropriate amount

[0024] Composition of semi-permeable membrane coating solution:

[0025] Cellulose acetate 90.0%

[0026] Macrogol 400 10.0%

[0027] Acetone: Water 3.0% (w / v)

[0028] Composition of moisture-proof coating solution:

[0029] Hypromellose 42.9%

[0030] 1,2-Propanediol 2.0% (v / v)

[0031] Talc 28.6%

[0032] Titanium dioxide 28.6%

[0033] Ethanol: Water 7.0% (w / v)

[0034] Using film coating technology, nisoldipine is made into single-layer osmotic pump controlled-release tablets, and one or both sides are laser or mechanically perforated to achieve the purpose of controlled...

Embodiment 2

[0036] This example was prepared using methods known in the pharmaceutical industry. The tablet contains the following ingredients by weight percentage:

[0037] Tablet composition:

[0038] Nisoldipine 2.9%

[0039] Polyoxyethylene (molecular weight: 200,000) 43.2%

[0040] Sodium chloride 43.4%

[0041] Starch 10.1%

[0042] Magnesium Stearate 0.4%

[0043] 10% povidone K30 ethanol solution appropriate amount

[0044] Composition of semi-permeable membrane coating solution:

[0045] Cellulose acetate 85.1%

[0046] Polyethylene glycol 200 14.9%

[0047] Acetone: Water 3.6% (w / v)

[0048] Moisture-proof coating liquid composition: with example 1

[0049] Using film coating technology, nisoldipine is made into single-layer osmotic pump controlled-release tablets, and one or both sides are laser or mechanically perforated to achieve the purpose of controlled release.

Embodiment 3

[0051] This example was prepared using methods known in the pharmaceutical industry. The tablet contains the following ingredients by weight percentage:

[0052] Tablet composition:

[0053] Nisoldipine 3.0%

[0054] Gum Arabic 34.1%

[0055] Sodium chloride 50.3%

[0056] Starch 11.1%

[0057] Magnesium Stearate 1.5%

[0058] 10% povidone K30 ethanol solution appropriate amount

[0059] Composition of semi-permeable membrane coating solution:

[0060] Cellulose acetate 85.0%

[0061] Dibutyl phthalate 15.0%

[0062] Acetone: Water 3.6% (w / v)

[0063] Moisture-proof coating liquid composition: with example 1

[0064] Using film coating technology, nisoldipine is made into single-layer osmotic pump controlled-release tablets, and one or both sides are laser or mechanically perforated to achieve the purpose of controlled release.

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Abstract

A release controlled nisoldipine tablet with single-layer osmotic pump for treating hypertension, angina pectoris, heart failure, etc contains nisoldipine, the release-controlling auxidiary chosen from sodium chloride, potassium chloride, glyceride behenate, etc, and other auxiliaries. Its advantages are sure and durable curative effect and low toxic by-effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a nisoldipine monolayer osmotic pump controlled-release tablet for treating hypertension, angina pectoris, left ventricular dysfunction and congestive heart failure. Background technique: [0002] The common tablet of nisoldipine available in the market is frequently taken, which is inconvenient to take, and the blood concentration fluctuates greatly. Invention content: [0003] The purpose of the present invention is to provide a nisoldipine single-layer osmotic pump controlled-release tablet with convenient administration, long-lasting effect, stable curative effect and little toxic and side effects. [0004] The purpose of the present invention is achieved like this: [0005] Preparation of the present invention contains following components by weight percentage: [0006] Nisoldipine 1-20% [0007] Excipients for controlled release 30-90% [0008] Other excipients bala...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/4422A61P9/04A61P9/10A61P9/12
Inventor 潘卫三吴学明
Owner SHENYANG PHARMA UNIVERSITY
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