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Ginseng and ophiopogon saponin drops and their preparing method

A technology of total saponins and ginsenosides, which can be used in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of inconvenient use for patients and high production costs, and achieve improved bioavailability, good quality, and safety Effects on Sexuality and Effectiveness

Inactive Publication Date: 2004-12-08
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the freeze-dried preparation has the disadvantages of high production cost and inconvenient use by patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Take 100g of red ginseng silk, add 800ml of 70% ethanol to soak overnight in a hot reflux extraction tank, heat and reflux for extraction for 1.5 hours, release the medicinal liquid, add 800ml of 70% ethanol to the dregs and extract for 1.5 hours, extract once, concentrate the extract to recover ethanol Until there is no alcohol smell, let it cool, put on the treated HPD-100 macroporous resin, absorb overnight, wash the column with water and test for α-naphthol and concentrated sulfuric acid, if it is negative, use 75% ethanol to wash the column and wash it. Collect the alcohol eluate until the eluate is almost colorless, recover the ethanol under reduced pressure until there is no alcohol smell, let it cool, extract with water-saturated n-butanol until the n-butanol layer is almost colorless, combine the n-butanol extracts and Concentrate under reduced pressure to dryness, extract powder, and vacuum dry the powder in an oven at 60°C for 4 to 5 hours to obtain 4.7 g of g...

Embodiment 2

[0145] Take 100g Radix Ophiopogon japonicus, add about 800ml 75% ethanol, soak overnight in a hot reflux extraction tank, heat reflux extraction for 1.5 hours, release the medicinal liquid, add 800ml 75% ethanol to the dregs, extract for 1.5 hours, extract three times, concentrate the extract to recover ethanol Until there is no alcohol smell, let it cool, put on the treated HPD-100 macroporous resin, absorb overnight, wash the column with water and test for α-naphthol and concentrated sulfuric acid, if it is negative, use 75% ethanol to wash the column and wash it. Collect the alcohol eluent until the eluent is nearly colorless, put the eluent through an aluminum oxide column, collect the column liquid, reclaim the ethanol under reduced pressure to dryness, and extract the powder to obtain 1.4g of radix radix radix saponin extract, wherein The content of Ophiopogon saponin can reach 60%.

Embodiment 3

[0147] Weigh 200g and 100g of Ophiopogon japonicus and red ginseng respectively, cut the red ginseng into sections, add 2400ml of 70% ethanol to heat and reflux for extraction three times, each time for 1.5 hours. Combine the extracts for 3 times, recover the ethanol under reduced pressure at 80°C until there is no alcohol smell and make the crude drug:medicine solution about 1:2, let it cool, centrifuge, take the processed HPD-100 macroporous resin column on the centrifugate, Elute with water until the test of α-naphthol and concentrated sulfuric acid is negative, then elute with 4 times the column volume of 70% ethanol and collect the eluate, concentrate the eluate at 80°C under reduced pressure to form a thick paste , dried under reduced pressure at 80° C., and pulverized to obtain 8.4 g of total ginseng saponins powder, wherein the content of total ginseng saponins reaches 60%.

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Abstract

A Chinese medicine in the form of dropping pills for treating cardiovascular and cerebrovascular diseases is prepared from ginseng and ophiopogon root. Its advantage is high contents of ginsenoside and ophiopogon saponin.

Description

Technical field: [0001] The invention relates to a Shenmai total saponin dripping pill preparation composed of effective parts extracted from traditional Chinese medicine red ginseng and Radix Ophiopogon japonicus and a preparation method thereof. Background technique: [0002] The ancient prescription Shendong Drink originated from Qin Jingming's "Syndrome Causes and Pulse Treatment" in the Ming Dynasty. It is composed of equal amounts of ginseng and Radix Ophiopogon. The main function is to replenish qi and solidify, nourish yin and promote body fluid, nourish the heart and rejuvenate the pulse; the Shenmai preparations developed according to the ancient prescription Shendongyin include Shenmai Granules, Shenmai Powder, and Shenmai Injection. It has been confirmed by pharmacological experiments that the effect of Shenmai injection on the cardiovascular system is to enhance myocardial contractility, increase cardiac output, expand peripheral blood vessels, increase blood su...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/704A61P9/00
Inventor 张锡昌阎志霞张来芳杨晓雷
Owner NANJING CHIA TAI TIANQING PHARMA
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