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Biologically active artificial teeth root and its preparation method

An artificial tooth root and bioactive technology, applied in the field of biomedical materials, can solve the problems of prolonging the release cycle of BMP, and achieve the effects of good biological activity, promoting deposition growth, good biological activity and inducing osteogenic effect.

Inactive Publication Date: 2004-12-29
SOUTHEAST UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem: The object of the present invention is to address the above-mentioned shortcomings of artificial tooth root materials, and propose a bioactive artificial tooth root whose surface BMP release period is prolonged, which is conducive to the full play of BMP-induced osteogenesis and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) First choose pure titanium to process the artificial tooth root;

[0025] (2) Surface activation treatment of the artificial tooth root: after ultrasonically cleaning the artificial tooth root with acetone, 70% alcohol, and distilled water in sequence, use 20% boiling H 2 o 2 Aqueous solution treatment, the treatment time is 45 minutes, take out and rinse, then soak in 4M NaOH aqueous solution at a temperature of 30-50°C for 24-36 hours, take out distilled water to rinse, and dry at 70°C.

[0026] (3) Biomimetic deposition treatment of calcium phosphate amorphous bottom layer: immerse the artificial tooth root treated with surface activation in the biomimetic calcification solution A at a temperature of 20°C. Ion 4.5mM, Calcium ion 12.5mM, Chloride ion 610.0mM, Hydrogen phosphate ion 5.0mM, Bicarbonate ion 18.0mM. The biomimetic calcification solution A was stirred with a magnetic stirrer, taken out after 12-24 hours of biomimetic deposition treatment, ultrasonica...

Embodiment 2

[0031] (1) First choose Ti6Al4V alloy to process the artificial tooth root;

[0032] (2) Surface activation treatment of the artificial tooth root: After ultrasonically cleaning the artificial tooth root with acetone, 70% alcohol, and distilled water in sequence, use 30% boiling H 2 o 2 Aqueous solution treatment, the treatment time is 90 minutes, take out and rinse, then soak in NaOH aqueous solution with a temperature of 60-70°C and a concentration of 8M for 24-36 hours, take out distilled water, rinse, and dry at 70°C.

[0033](3) Biomimetic deposition treatment of calcium phosphate amorphous bottom layer: immerse the artificial tooth root treated with surface activation in the biomimetic calcification solution A at a temperature of 30°C. Ion 4.5mM, Calcium ion 12.5mM, Chloride ion 610.0mM, Hydrogen phosphate ion 5.0mM, Bicarbonate ion 18.0mM. The biomimetic calcification solution A was stirred with a magnetic stirrer, taken out after 24-36 hours of biomimetic deposition ...

Embodiment 3

[0038] (1) First choose Ti6A14V alloy to process the artificial tooth root;

[0039] (2) Surface activation treatment of the artificial tooth root: after ultrasonically cleaning the artificial tooth root with acetone, 70% alcohol, and distilled water in sequence, use boiling H with a concentration of 30%. 2 o 2 Aqueous solution treatment, the treatment time is 90 minutes, take out and rinse, then soak in NaOH aqueous solution with a temperature of 60-70°C and a concentration of 8M for 24-36 hours, take out distilled water, rinse, and dry at 70°C.

[0040] (3) Biomimetic deposition treatment of calcium phosphate amorphous bottom layer: immerse the artificial tooth root treated with surface activation in the biomimetic calcification solution A at a temperature of 30°C. Ion 4.5mM, Calcium ion 12.5mM, Chloride ion 610.0mM, Hydrogen phosphate ion 5.0mM, Bicarbonate ion 18.0mM. The biomimetic calcification solution A was stirred with a magnetic stirrer, taken out after 24-36 hours...

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Abstract

The present invention is one kind of artificial tooth root material with surface porous Ca-P bioactive ceramic coating layer and bone morphogenetic protein and its preparation process. The artificial tooth root material consists of metal tooth root substrate, one layer of double-layered porous Ca-P bioactive ceramic coating layer on the surface of the metal substrate, and bone morphogenetic protein covering the bioactive ceramic coating layer. The preparation process includes machining artificial tooth root with titanium or titanium alloy; surface activating the artificial tooth root, two-step bionic deposition to form the porous biological Ca-P ceramic coating layer comprising the compact non-crystal calcium phosphate base layer and the porous crystalline bone-like apatite surface layer; and soaking the artificial tooth root inside mixed solution comprising bone morphogenetic protein and buffering phosphate solution.

Description

technical field [0001] The invention relates to a bioactive artificial tooth root and a preparation method thereof, in particular to an artificial tooth root material with porous calcium-phosphorus bioactive ceramic coating and bone morphogenetic protein (BMP) prepared by a bionic method on the surface and a preparation method thereof. It belongs to the technical field of biomedical materials. Background technique [0002] Artificial dental implants can restore the function of missing natural permanent teeth, which allows patients with tooth loss that cannot be repaired by traditional methods to receive fundamental treatment and improve their quality of life. The commonly used artificial tooth roots are metal materials, because they are biologically inert materials, and cannot form a firm physiological combination with the gum tissue. After implantation, they often loosen, resulting in the failure of artificial tooth root replacement. Using surface...

Claims

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Application Information

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IPC IPC(8): A61C8/00A61C13/00A61K6/02
Inventor 储成林浦跃朴林萍华薛小燕沈刚
Owner SOUTHEAST UNIV
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