Nano superoxide dismutase and preparation method

A superoxide and nanotechnology technology, applied in the field of nanometerization of enzymes and their preparation, can solve the problems of no direct nanoization of SOD, poor direct absorption by skin, short half-life, etc. The effect of high energy utilization

Inactive Publication Date: 2005-01-12
王成余
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, SOD has certain immunogenicity due to its large molecular weight (greater than 30,000), short half-life (half-life is only a few minutes), the influence of oral digestive juice, poor skin direct absorption when external use, and its own immunogenicity, so its application is restricted. very restrictive
At present, there is no report on the direct nanotechnology of SOD

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Nano SOD liquid: glycerin or other oily liquids: surfactant mixing=1-10: 1-10: 1-5, after forming emulsion, dropwise add surfactant (as n-butanol) wherein, add dropwise to At a certain amount, the system becomes a clear and transparent water-in-oil (W / O) microemulsion;

Embodiment 2

[0048] Nano-SOD liquid: glycerol = 15:10, changing the amount of surfactant (such as AE03+TX10) 1-5, you can get single-phase, two-phase or three-phase microemulsion;

Embodiment 3

[0050] Mix lecithin: cholesterol 2-10: 1-5, add appropriate amount of n-butanol to dissolve it, then add purified SOD liquid after ultra-high pressure nano-homogenization treatment, 100W ultrasonic emulsification, electromagnetic stirring at room temperature (500r / min) Make it a stable W / O emulsion.

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Abstract

When the diameter of a nanometer super oxide dismutase is 10-200nm, its antioxidative activity increases more than 10 times, skin and mucosa absorption rate is over 90%, half-life prolongs to more than tow orders, it can play the role of clearing free radicals in cells with stronger resisting over oxidation to lipid. The preparation is to take SOD from plants or animals as the raw material applying a nm super high voltage uniformity technology to process it to SOD moleculars, then applying slight emulsification or liposome technolgies to scatter the nm moleculars to form nm SOD micro drops or applying supersonic fluid technology to produce SOD micro capsules.

Description

[0001] Field [0002] The invention relates to a nanometerization of an enzyme and a preparation method thereof. Specifically, it relates to nano-sized superoxide dismutase and its preparation method (superoxide dismutase, SOD). Jet technology) to nanometerize SOD molecules, and add various drugs according to different purposes to form a variety of formulations, which are used in the fields of health care and treatment. Background technique [0003] SOD is the only enzyme recognized by the international biomedical community that can remove superoxide anion free radicals produced in cells in the human body. It has strong anti-oxidation, anti-radiation, anti-inflammatory, anti-aging, anti-mutation and anti-cancer effects. Hyperbaric oxygen poisoning, emphysema, diabetes, autoimmune diseases, various inflammations, cardiovascular and cerebrovascular diseases, cancer and other diseases have excellent effects, and can be used to delay aging and prevent and treat various senile dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/18A61K9/08A61K9/107A61K9/20A61K9/48A61K9/50A61K38/44C12N9/02
Inventor 王成余王刚王庆辉王强
Owner 王成余
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