Preparation of super paramagnetic nano particles dispersible in water

A nanoparticle and easy-to-disperse technology, applied in the field of preparation of superparamagnetic nano-ions, can solve the problems of complex reaction steps, limited drug loading methods, wide particle size distribution, etc., and achieves a simple and easy preparation method, good application value, Evenly distributed effect

Inactive Publication Date: 2005-02-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reaction steps of this method are complicated, the particle size distribution is wide, and if it is to be applied to the targeted drug delivery in vivo or other methods, the drug loading method is very limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 2.13 grams of medium polyalkyd polymer, add 5ml of ethanol and 45ml of water, ultrasonic for 10 minutes, add 0.743 grams of FeCl 3 .6H 2 O and 0.382 g FeCl 2 .4H 2 O. Sonicate for 5 minutes, pass N 2 , add NaOH dropwise, turn the magnetic stirring knob to the maximum position of about 1800rpm, heat at about 75°C, and check the pH online. When the pH is between 9 and 10.45 for about 50 minutes, stop adding NaOH and heating. After centrifugation, the average particle size measured by PCS is about 5nm. The particle size of iron oxide particles measured by transmission electron microscopy is 3nm. In nanoparticles, it mainly exists as a single primary particle. Compared with other methods, the superparamagnetic nanoparticles synthesized by the method have the characteristics of small particle size, uniform distribution, no obvious aggregation, and good dispersibility and stability in water.

Embodiment 2

[0019] Weigh 4.8 grams of high poly alkyd polymer, add 20ml of water, add 1.235 grams of FeCl 3 .6H 2 O, pass into N 2 , sonicate for 30 minutes. Weigh 0.612 g of FeCl 2 .4H 2 O was added to the three-way bottle and ultrasonicated for 10 minutes. Access to N 2 , electric stirring 1093rpm, drop NaOH 1 ~ 2 drops / second (3.149 grams of NaOH + 130ml water), until the color of the reaction solution turns black. Heating was continued at 75°C for 30 minutes. After centrifugation, the average particle size measured by PCS is about 500nm, and the particle size of iron oxide particles measured by transmission electron microscopy is 30nm, and the nanoparticles mainly exist in the form of dispersive collection of five primary particles. Uniform particle size distribution, no obvious aggregation, good dispersibility and stability in water.

Embodiment 3

[0021] Weigh 1.022g oligomeric alkyd polymer, add 5ml ethanol and 45ml water, ultrasonic for 10 minutes, add 0.823g FeCl 3 .6H 2 O and 0.392 g FeCl 2 .4H 2 O. Sonicate for 5 minutes, pass N 2 , add NaOH dropwise, turn the magnetic stirring knob to the maximum at about 1800rpm, heat at about 75°C, and check the pH online. When the pH is between 9 and 10, stop adding NaOH and continue heating for 50-100 minutes. After centrifugation, PCS test The average particle size is about 200nm, and the particle size of iron oxide particles measured by transmission electron microscope is about 18nm; in the nanoparticles, it mainly exists in the form of two primary particles scattered and assembled. Uniform particle size distribution, no obvious aggregation, good dispersibility and stability in water.

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PUM

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Abstract

A process for preparing the super-paramagnetic nanoparticles dispersed in water easily includes such steps as mixing the polymer chelating agent with Fe ions, dripping alkali while reacting to generate inn oxide and continuously dripping alkali until pH=9-10.

Description

technical field [0001] The invention relates to a preparation method for easily dispersed superparamagnetic nanometer ions in water, in particular to a method for synthesizing superparamagnetic nanoscale iron oxide particles by using a polymer chelating agent. used in the biomedical field. Background technique [0002] In recent years, the great application value of magnetic nanoparticles in bioseparation, MRI contrast imaging, and controlled release of drugs has received great attention. There are more and more studies on the preparation and application of iron oxide nanoparticles, but iron oxide nanoparticles are easy to aggregate due to their high surface energy, and it is difficult to maintain a particle size distribution at the nanometer scale. Foreign patented technology adopts surface modification methods such as dextran molecules. More mature products such as CLIO are cross-linked polymers of bromoacetic acid and polyvinyl alcohol (PVA) on the surface of superparama...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/02H01F1/11
Inventor 刘书朋魏晓慧徐宇虹
Owner SHANGHAI JIAO TONG UNIV
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