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Absorptive medical chitosan suture and its producing method

A technology of chitosan and suture, which is applied in the field of medical surgical suture materials, can solve the problems of susceptibility to allergies, decreased mechanical strength, and poor absorbability, and achieves safe and easy-to-obtain solvents, high tensile strength, and high degree of deacetylation Effect

Inactive Publication Date: 2005-03-02
上海美宝生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process of catgut is backward, pollutes the environment, has poor absorbability, is prone to allergies and antigenic reactions; the production cost of PGA sutures remains high, and the scope of use is affected. In addition, the high moisture content of PGA makes the material easy to hydrolyze and deteriorate. The mechanical strength decreases, the quality of the suture is seriously affected, and the degradation product of PGA is lactic acid, which has a certain impact on the healing of suture tissue

Method used

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  • Absorptive medical chitosan suture and its producing method
  • Absorptive medical chitosan suture and its producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Dissolve 60 g of chitosan with a viscosity of 800 mPa S and a degree of deacetylation of 90% in 1.8% acetic acid, add 6 g of urea, and then add 0.4% sodium acetate by weight of chitosan , 1.4% sorbitol, and 0.3% absolute ethanol are prepared into a slurry with a concentration of 3.0%. Stir at 20°C for 3-4 hours to form a uniform chitosan spinning slurry. The slurry is filtered with 300-mesh poplin cloth, the pressure is controlled at 0.2-0.3Mpa, and then vacuumized for degassing. The defoamed slurry is transported to the spinning cap with a metering pump. The hole diameter of the spinning cap was 0.07 mm, and the number of holes was 120 holes. The coagulation bath is a mixed solution of sodium hydroxide and ethanol. The content of sodium hydroxide is 4.8%. Continue to stretch 1.3 times in hot water at ℃, and the total stretch ratio is 1.43. The stretched fibers are first washed with deionized water until neutral, and then soaked with absolute ethanol. Af...

Embodiment 2

[0026] Example 2: Dissolve 60 g of chitosan with a viscosity of 2000 mPa S and a degree of deacetylation of 91% in 1.7% acetic acid, add 15 g of urea, and then add 0.8% sodium acetate by weight of chitosan , 1.0% sorbitol, and 0.8% absolute ethanol are prepared into a slurry with a concentration of 3.0%. Stir at 20°C for 3-4 hours to form a uniform chitosan spinning slurry. The slurry is filtered with 300-mesh poplin cloth, the pressure is controlled at 0.2-0.3Mpa, and then vacuumized for degassing. The defoamed slurry is transported to the spinning cap with a metering pump. The hole diameter of the spinning cap is 0.08 mm, and the number of holes is 160 holes. The coagulation bath is a mixed solution of sodium hydroxide and ethanol. The content of sodium hydroxide is 10%. Continue to stretch 1.4 times in hot water at ℃, and the total stretch ratio is 1.54. The stretched fibers are first washed with deionized water until neutral, and then soaked with absolute ethanol. Aft...

Embodiment 3

[0027] Example 3: Dissolve 60 g of chitosan with a viscosity of 3000 mPa S and a degree of deacetylation of 92% in 1.5% acetic acid, add 30 g of urea, and then add zinc acetate with a weight of 1.2% of chitosan , 0.6% sorbitol, and 1.5% absolute ethanol are prepared into a slurry with a concentration of 3.0%. Stir at 20°C for 3-4 hours to form a uniform chitosan spinning slurry. The slurry is filtered with 300-mesh poplin cloth, the pressure is controlled at 0.2-0.3Mpa, and then vacuumized for degassing. The defoamed slurry is transported to the spinning cap with a metering pump. The hole diameter of the spinning cap is 0.10 mm, and the number of holes is 200 holes. The coagulation bath is a mixed solution of sodium hydroxide and ethanol, the content of sodium hydroxide is 20%, the temperature of the coagulation bath is 3.0°C, stretch 1.1 times in hot water at 70-80°C after leaving the coagulation bath, and then stretch it at more than 90°C Continue to stretch 1.4 times in ...

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Abstract

The present invention provides a absorptive medical chitosan suture and its production process. The chitosan material is produced into the absorptive medical chitosan suture through a wet spinning process including the steps of compounding the chitosan into spun slurry in certain concentration, filtering, defoaming, metering, solidification, stretching, washing, oiling, twisting and sterilizing. The production process uses safe and cheap solvent system comprising acetic acid and acetate with pH greater than 3, and the chitosan slurry has high viscosity, high deacetylation degree and high stability. The absorptive medical chitosan suture has high tension strength and can meet the requirement of clinical use.

Description

technical field [0001] The present invention relates to medical surgical suture materials. Specifically, it is a suture made of chitosan raw material and its production technology. Background technique [0002] At present, surgical sutures in medical materials at home and abroad are divided into two types: absorbable and non-absorbable. The raw materials of absorbable sutures include pure natural, artificial, and composite materials made of natural materials and artificial synthesis. Currently, the commonly used absorbable sutures are catgut and PGA absorbable sutures. The production process of sheep catgut is backward, pollutes the environment, has poor absorbability, is prone to allergies and produces antigenic reactions; the production cost of PGA sutures remains high, and the scope of use is affected. The mechanical strength decreases, and the quality of sutures is seriously affected. Moreover, the degradation product of PGA is lactic acid, which has a certain impact o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/03A61B17/04A61L17/10D01F1/00
Inventor 商庆新易智强
Owner 上海美宝生命科技有限公司
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