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Ophthalmic solution containing borneol and usage thereof

A solution and ophthalmology technology, applied in glasses/protective glasses, glasses/goggles, optics, etc., can solve the problems of increasing inconvenience and achieve the effect of relieving heat and moisturizing sensation

Active Publication Date: 2005-06-22
上海卫康光学眼镜有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This increases the inconvenience for people to use

Method used

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  • Ophthalmic solution containing borneol and usage thereof
  • Ophthalmic solution containing borneol and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Prepare various reagents according to the recipes in Table 1.

[0083] Component

Recipe 1

Recipe 2

Recipe 3

Recipe 4

Recipe 5

ice flakes

0.0001

0.001

3

50

80

boric acid

50

20

13

5

0.001

sodium borate

---

0.5

1.0

0.7

---

Disodium phosphate

80

40

9

3

0.05

citric acid

0.001

50

18

3

0.03

Sodium chloride

0.02

1

1.8

4.5

7.5

Poloxamer

(BASF Corporation)

0.01

2

16

70

100

sodium bicarbonate

0.1

0.1

0.1

0.1

0.1

TRIS-HCl

1

1

1

1

1

Potassium sorbate

---

---

1

3

7.98

sodium hydroxide or hydrochloric acid

(concentration is 1N)

Regulate acid-base

...

Embodiment 2～5

[0088] Examples 2-5 illustrate the effect of solutions of the present invention on cleaning protein deposits accumulated on the surface of hydrophilic contact lenses (FDA Class IV, for example, J&J Survue® hydrogel lenses with a water content of 58%).

[0089] The cleaning ability of lens deposits can be compared by the following method: use the solution to be tested to treat soft lenses that have been pre-deposited with lysozyme and calf tear protein solution (called artificial tears) (here the water content 58% of the FDA Type IV soft lens), respectively measure the UV absorbance value of the artificial tear before and after treating the lens, and the UV absorbance value of the solution after treating the lens. The difference in the UV absorbance value of the artificial tear before and after treating the lens is The amount of protein deposited on the lens, and the UV absorbance value of the solution to be tested is the amount of protein eluted, and the ratio of the two is the...

Embodiment 6～13

[0095] Examples 6-13 illustrate the effect of the solution of the present invention on the bactericidal effect.

[0096] Test challenge The experimental strains used were Staphylococcus aureus (ATCC6538), Pseudomonas aeruginosa (ie, Pseudomonas aeruginosa, ATCC9027), Escherichia coli (8099) and Candida albicans (ATCC10231). After each microorganism is cultured in a suitable medium to a suitable bacterial concentration (such as 107~108cfu / ml), each solution to be tested is inoculated with a certain amount of challenging microbial suspension, and the number of bacteria after inoculation is 105~106cfu / ml , The number of bacteria can be evaluated by turbidity method or culture method. The volume of the inoculum suspension should not exceed 1% of the total volume. Shake to make the bacteria liquid evenly distributed, place the test solution at a suitable temperature after inoculation to allow the inoculated bacteria to grow normally, and count the colonies of the test solution aft...

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PUM

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Abstract

This invention provides a solution and its usage used for cleaning, disinfecting storing cryptomorphic glasses and used as an in-eye moist solution, including borneol composition. When contacting with eyes, it provides comfortable cool sense to user eyes to ease up swelling and heating of eyes due to wearing cryptomorphic glasses.

Description

technical field [0001] The present invention relates to a solution for cleaning, disinfecting, storing contact lenses and as intraocular moistening solution and its application. Background technique [0002] Currently widely used contact lenses can be roughly divided into two categories: hard contact lenses and soft contact lenses. The hard contact lens material can be formed by acrylate polymerization, such as polymethyl methacrylate (PMMA), etc., or it can be a rigid gas formed by siloxane acrylate and fluorosilicone methacrylate. Permeable (rigid gas permaeable, RGP) lenses. Soft lenses are currently mostly composed of polymerized hydrophilic monomers such as 2-hydroxyethyl methacrylate (HEMA). [0003] Hard lenses are less deformable and have a strong foreign body sensation when worn in the eyes, and the wearer has a certain repulsion to them. Relatively speaking, soft lenses are very soft and comfortable to wear, and are more acceptable to consumers. [0004] Usually...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04G02C13/00
Inventor 钟海波
Owner 上海卫康光学眼镜有限公司
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