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Gancilorvir dispersable tablet and its preparation

A technology for ganciclovir and dispersible tablets, applied in the field of antiviral ganciclovir dispersible tablets and preparation thereof, can solve the problems of inconvenience for the elderly and children, the capsules can only be swallowed, and the dosage is large, and the invention can achieve The effect of convenient administration, short disintegration time and high bioavailability

Inactive Publication Date: 2005-07-06
HUAZHONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Because the single dose of the capsule is relatively large (250mg), the dosage is relatively large each time (4 capsules / time), and the capsule can only be swallowed, which brings inconvenience to patients with dysphagia, the elderly and children

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 per 1000 dosage

[0018] Ganciclovir 250g

[0019] Microcrystalline Cellulose 75g

[0020] Low-substituted hydroxypropyl cellulose 25g

[0021] Polyvinylpyrrolidone (K 30 ) 5g

[0022] Lactose 40g

[0023] Magnesium Stearate 5g

[0024] Preparation:

[0025] Get the ganciclovir, microcrystalline cellulose low-substituted hydroxypropyl cellulose and lactose of the prescribed amount, sieve, mix well, and cross-linked polyvinylpyrrolidone is made into 50g / L aqueous solution, add in the above-mentioned mixture, make soft Material, passed through a 14-mesh sieve, granulated, wet granules were dried at 50-60°C for 4 hours, granulated, added with magnesium stearate, mixed evenly, and pressed into tablets.

[0026] Ganciclovir

[0027] The preparation method is the same as in Example 1, wherein polyvinylpyrrolidone is formulated into a 30 g / L aqueous solution.

[0028] Ganciclovir

[0029] The preparation method is the same as in Example...

Embodiment 4

[0030] Embodiment 4 per 1000 dosage

[0031] Ganciclovir 250g

[0032] Microcrystalline Cellulose 60g

[0033] Cross-linked polyvinylpyrrolidone 40g (plus 20g inside and outside)

[0034] Lactose 42g

[0035] Magnesium Stearate 5g

[0036] Polyvinylpyrrolidone (K 30 ) 3g

[0037] The preparation method is the same as in Example 1, wherein the polyvinylpyrrolidone is formulated into a 10 g / L ethanol solution, and a 40% ethanol aqueous solution is used as the solvent.

Embodiment 5

[0038] Embodiment 5 per 1000 dosage

[0039] Ganciclovir 250g

[0040] Microcrystalline Cellulose 86g

[0041] Cross-linked polyvinylpyrrolidone 25g

[0042] Lactose 30g

[0043] Hypromellose 4g

[0044] Magnesium Stearate 5g

[0045] The preparation method is the same as in Example 1, wherein the hypromellose is formulated into a 10 g / L aqueous solution.

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PUM

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Abstract

The invention provides a Gancilorvir dispersable tablet and its preparation, wherein the dispersion tablet comprises 62.5 wt% of Ganciclovir, 10-25% of crystalline cellulose, or calcium hydrogen phosphate and / or starch, 1-10% of sodium carboxymethylstarch, or low substituted methylcellulose propylene glycol ether and / or cross bonding polyvinylpyrrolidone or crosslinked sodium carboxymethylcellulose, 0.1-1.4% of polyvinylpyrrolidone, or methyl hydroxypropylcellulose, 5-15% of lactose, 0.5-1.4% of magnesium stearate. The preparing process comprises sieving, mixing, granulating, drying, and tabletting.

Description

technical field [0001] The invention relates to an antiviral drug ganciclovir dispersible tablet and a preparation method thereof. Background technique [0002] Ganciclovir is 9-(1,3-dihydroxy-2-propoxymethyl)guanine. The English name is gancicLovir. [0003] Ganciclovir is another broad-spectrum anti-herpes virus drug with high efficiency, low toxicity and strong selectivity developed after Acyclovir. The difference between it and Acyclovir is that there is another Hydroxymethyl, in vitro, is effective against all herpes viruses, including CMV. It inhibits its synthesis by competitively inhibiting viral DNA polymerase and binding to viral DNA to become the termination code of viral DNA, showing antiviral effect. Oral bioavailability of this product is extremely low (6%-9%), but it is convenient to administer because of the oral form, and oral ganciclovir can obtain good effect on the primary prevention of CMV disease in selected patients. Therefore, Ganciclovir capsules ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/522A61P31/22
Inventor 杨光富程靖陈琼
Owner HUAZHONG NORMAL UNIV
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