Water-in-oil emulsion composition

An emulsified composition, water-in-oil type technology, applied in the directions of drug combination, emulsion delivery, cosmetic preparations, etc., can solve the problems of poor stretching, unsatisfactory taste, high stickiness, etc. Excellent stability over time, good stability and usability over time, and good usability

Active Publication Date: 2005-07-13
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when using a water-in-oil emulsifier blended with a salicylic acid derivative, it does

Method used

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  • Water-in-oil emulsion composition
  • Water-in-oil emulsion composition
  • Water-in-oil emulsion composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0058] Hereinafter, examples are given and the present invention will be described in more detail, but the present invention is not limited to the following examples. In addition, unless otherwise specified, the compounding amount of the component is represented by mass % with respect to the system to be compounded.

[0059] Before the examples, the evaluation method used in each example will be described.

[0060] [usability (opening on skin)]

[0061] A group of 60 test subjects (30 men and women each) used the emulsified composition (sample) of each Example and Comparative Example, and evaluated whether the emulsion spread on the skin was good or bad according to the following criteria.

[0062] (Evaluation)

[0063] ◎: 30 or more testers feel that the spread on the skin is good

[0064] ○: 10 to 29 testers feel that the spread on the skin is good

[0065] △: 5 to 9 testers felt that the spread on the skin was good

[0066] ×: 4 or less testers feel that the spread on ...

Embodiment 1～6

[0100] A water-in-oil type emulsion composition having an example composition shown in the following Table 2 was prepared, which was used as a sample, and the feeling in use and stability were evaluated according to the following evaluation criteria. The results are shown in Table 2 together.

[0101] (preparation method)

[0102] (1)-(4) in Table 2 and the oil phase part of (15) were mixed uniformly. On the other hand, (5) to (14) were added to (16) and dissolved completely to prepare the water phase. This water phase part was gradually added to the oil phase part, and uniformly dispersed to obtain a W / O emulsion part (water-in-oil type emulsion composition). Also, in Table 2, "Cetyl Dimethicone Polyol (*1) "ABILEM90" (manufactured by Goldshyumit Co., Ltd.) was used, and "decaglyceryl pentaisostearate" was used "Decaglyn 5-IS" (manufactured by Nikko Chemicals Co., Ltd.).

[0103] Compare

[0104] implement

[0105] From the results shown in Tables...

Embodiment 7

[0106] (Example 7: whitening emulsion) (mass%)

[0107] (1) Decamethylcyclotetrapolysiloxane 20.0

[0108] (2) Tris(decanoyl / capric acid) glyceride 10.0

[0109] (3) (Dimethicone / Vinyl Dimethicone) Crosslinking Polymerization 3.0

[0110] ("Trefoil E506"; manufactured by Ray Dou Corning Co., Ltd.)

[0111] (4) Cetyl dimethicone polyol (manufactured by "ABIL EM90" Gold 2.0 Doshimito Co., Ltd.)

[0112] (5) 1,3-Butanediol 5.0

[0113] (6) Polyethylene glycol 11000 2.0

[0114] (7) Glycerin 5.0

[0115] (8) paraben appropriate amount

[0116] (9) Potassium 4-methoxysalicylate 5.0

[0117] (10) Citric acid amount

[0118] (11) Sodium citrate 0.1

[0119] (12) Sodium chloride 1.0

[0120] (13)EDTA·3Na·2H 2 O 0.05

[0121] (14) Appropriate amount of spices

[0122] (15) Ion-exchanged water residual

[0123] (preparation method)

[0124] To the substance in which (1) to (4) and (14) were uniformly dispersed, the substance in which (5) to (13) was uniformly dissolved in (...

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PUM

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Abstract

The present invention provides a water-in-oil type that does not impair the function of the component in a system containing a salicylic acid derivative (alkoxysalicylic acid, etc.), has good emulsification stability over time, and is excellent in usability emulsified composition. The water-in-oil emulsified composition contains (a) a salicylic acid derivative (such as methoxysalicylate, ethoxysalicylate, etc.) and (b) in an aqueous phase (inner phase). ) salts, and (c) polyethylene glycol with a molecular weight of 1,000 to 200,000, and if necessary, the oil phase (external phase) contains 30% by mass or more of the oil phase (external phase) that is liquid at normal temperature silicone oil.

Description

technical field [0001] The present invention relates to a water-in-oil (W / O) emulsion composition mainly used as an external preparation for skin. More specifically, it relates to a water-in-oil emulsified composition containing a salicylic acid derivative and having good temporal stability and usability. Background technique [0002] In recent years, when salicylic acid is blended into a water-in-oil emulsified composition, emulsified particles coalesce over a certain period of time to destabilize the system, and as a result, there are stability problems such as separation. Therefore, in order to prevent delamination, methods such as adding lipophilic emulsifiers or adding wax to the external phase (oil phase) are used to achieve stabilization. Therefore, when a water-in-oil emulsifier containing a salicylic acid derivative is used, it does not spread well, has a highly sticky feeling in use, and is not satisfactory in terms of palatability. [0003] On the other hand, it...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/19A61K8/30A61K8/36A61K8/365A61K8/72A61K8/86A61K9/107A61P17/16C08L83/04
Inventor 中村忠司鹿子木宏之
Owner SHISEIDO CO LTD
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