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Coating method of vitamin C

A vitamin and coating technology, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low coating rate and uneven coating thickness, and achieve uniform coating. , The effect of reducing unit cost and reducing environmental pollution

Inactive Publication Date: 2005-08-10
WUHAN SUNHY BIOLOGICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the disadvantages of uneven coating thickness and low coating rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: 40 kg of vitamin C, 5 kg of ethyl cellulose (or ethyl cellulose, or carboxymethyl cellulose) and 100 L of cyclohexane were placed in an organic solvent reaction axe, and refluxed at 80-85 ° C for 1-2 Hours, and then drop the temperature by 1-3°C every 5 minutes to 30-40°C, vitamin C is wrapped in the wall, forming microcapsules of 40-200 mesh, after vacuum drying, the required coated vitamin C is obtained .

Embodiment 2

[0014] Example 2: 35 kg of vitamin C, 3 kg of ethyl cellulose, 3 kg of carboxymethyl cellulose and 100 L of cyclohexane were placed in an organic solvent reaction axe, refluxed at 80-85 ° C for 1-2 hours, and then dropped by 1 every 5 minutes The speed of -3°C lowers the temperature to 30-40°C, vitamin C is wrapped in the wall to form microcapsules of 40-200 mesh, and after vacuum drying, the required coated vitamin C is obtained.

Embodiment 3

[0015] Example 3: Place 38 kg of vitamin C, 5 kg of ethyl cellulose, 3 kg of carboxymethyl cellulose, 2 kg of polypropylene and 100 L of cyclohexane into an organic solvent reaction axe, reflux at 80-85 ° C for 1-2 hours, and then Reduce the temperature by 1-3°C in 5 minutes to 30-40°C, vitamin C is coated in the wall, forming microcapsules of 40-200 mesh, and after vacuum drying, the required coated vitamin C is obtained.

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PUM

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Abstract

A process for coating on the surface of VC particle by high-molecular non-solvent temp-varying phase separation method includes separating the liquid phase of high-molecular material as wass material from continuous phase, coating in on the surface of VC particle to become microsphere, and vacuum drying. Its advantages are high coating uniformity, slow release, and high VC activity.

Description

technical field [0001] The invention relates to a coating technology, in particular to a vitamin C coating method. technical background [0002] Vitamin C, also known as ascorbic acid, exists in two forms in nature, the reduced form L-ascorbic acid and the oxidized form L-deoxyascorbic acid. Most vitamin C exists in reduced form. At present, vitamin C has been paid more and more attention as an essential functional nutrient additive in aquatic animal feed. However, the performance of vitamin C is very unstable, and it is easily oxidized by air in an alkaline or acidic environment. Physical and chemical factors such as ultraviolet radiation, heating process, and coexistence with metal ions can all destroy vitamin C. Therefore, in the process of feed production, the actual amount of vitamin C added should be greater than the theoretical demand. At present, the actual amount of vitamin C added to the feed is mainly based on two points: one is the nutritional requirements of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/375A61K47/38A61P3/02
Inventor 詹志春
Owner WUHAN SUNHY BIOLOGICAL
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