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Sample collecting device and mass spectrometry of device

A technique for sample collection and mass spectrometry, applied in the field of sample collection devices and mass spectrometry devices, and can solve problems such as large problems, no convenient and sensitive mass spectrometry method for detecting contaminants or contaminants, and high cost

Inactive Publication Date: 2005-08-31
DIAKYNE PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently available tests are cumbersome and expensive, and services are out of reach of the general population, especially in underdeveloped areas, where the problem is often greatest
Furthermore, there are no convenient and sensitive mass spectrometric methods for detecting contaminants or contamination in fluids such as water or lubricants

Method used

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  • Sample collecting device and mass spectrometry of device
  • Sample collecting device and mass spectrometry of device
  • Sample collecting device and mass spectrometry of device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1: Sample Collection and Application

[0083] Samples may be collected and applied to the selected collection matrix of the invention in a conventional manner well known in the art.

[0084] For example, blood from a subject can be collected using a kit that includes a sheathed, retractable, spring-loaded "lancet" as part of a sampling kit that also contains an enclosed ethanol-saturated wipe , or cotton swab, to pre-clean the skin area to be punctured to avoid unnecessary sample contamination.

[0085] It will be appreciated, however, that the collection of other bodily fluid samples, such as urine and sweat, or other fluids such as water or oil and other lubricants, will not require most of the components of blood collection specified above, but exclusion of contamination is still important. Conventional techniques for this are known to those skilled in the art.

[0086] A fluid sample, any fluid of interest, can be applied to the collection matrix for analy...

Embodiment 2

[0088] Example 2: Sample collection device

[0089]An example of one type of sample collection device of the present invention, particularly a collection device suitable for collecting blood samples, contains an inert fluid-absorbent matrix, most preferably a fibrous cellulose matrix (Whatman 540, also 541, 542 and other cellulose filter papers , Whatman International Ltd, Maidstone, England), typically shaped as a small tablet-sized disc. The matrix is ​​fixed or enclosed in a small, lightweight, disposable or recyclable support (disc support or solid support material). Ideal supports are made of a relatively rigid material (eg plastic, cardboard or similar). The device is designed so that a drop of blood or body fluid can be placed on the absorbent matrix and the device can be sealed at the collection site. Thus, fixed samples can be easily transported by mail or express mail to the sample analysis center and / or stored.

[0090] Of course the device can be used for other ...

Embodiment 3

[0105] Embodiment 3: sample analysis system

[0106] Traditionally, quantification by LA-ICP-MS has been accomplished by controlling the energy of the laser coupled to the sample to ensure uniform ablation properties and transfer of uniform amounts of solids to the analytical plasma. Although this method is recommended by many when the nature of the matrix can be secured (eg glass or similar), there are obvious problems associated with normalization of coupling and transfer efficiencies when the matrix is ​​non-uniform. Furthermore, it is extremely difficult to ensure uniform ablation when the characteristics of the sample surface also vary.

[0107] Until the present invention, the laser ablation ICP-MS technique was at best a semi-quantitative technique, and more generally a comparative technique for determining trace element levels in any solid material. In this embodiment of the invention, the quantification of LA-LCP-MS is achieved by quantifying the amount of debris (ab...

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PUM

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Abstract

A sample collection device is described comprising a support of an inert absorbent matrix carrying a fluid sample. The device may or may not contain a lancet. Also described with respect to this sampling device is a method for using a mass spectrometer in a laboratory, in which a sample in its matrix is ​​ionized and multiple elements are detected. Results may or may not be quantified from the original sample and an internal ionization reference sample may also be used.

Description

technical field [0001] The present invention relates to methods and devices for sample collection and simultaneous detection and / or quantification of multiple trace elements in fluid samples. Background technique [0002] A wide variety of trace metals and other elements are essential for good health and well-being in humans and other animals; deficiencies in essential elements have been shown to cause general malaise and lead to the induction of specific diseases, often resulting in death. For many essential trace elements, not only the absolute concentration, but also the balance between elements has a profound impact on health. For example, selenium deficiency has been implicated in the etiology of iodine deficiency disorders in humans, while copper deficiency with high levels of manganese may be responsible for bovine spongiotic encephalopathy (BSE) and the related new human variant Creutzfeldt-Jakob Predisposing factors or causes of disease (Creutzfeldt-Jakob Disease) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/10G01N30/72G01N33/487G01N27/64G01N33/10G01N27/62
CPCH01J49/0418G01N33/48714H01J49/0009G01N33/10B01L2300/0825A61B5/151B01L2300/045H01J49/105B01L2300/0672A61B5/1411B01L3/5023A61B5/150022A61B5/150305A61B5/150358A61B5/150412A61B5/150503A61B5/150633A61B5/150717A61B5/150786A61B5/150969A61B5/15105A61B5/15142G01N1/10
Inventor R·J·沃特林H·K·赫伯特
Owner DIAKYNE PTY LTD
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