Process for the production of methionine

A technology of methionine and amino group is applied in the field of preparation of methionine crystal, which can solve the problems of low solubility, difficult recovery of biocatalysts, and inability to increase the dissolved accumulation of methionine.
CN1671855AInactive Publication Date: 2005-09-21NIPPON SODA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NIPPON SODA CO LTD
Publication Date
2005-09-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

A practical method for producing methionine is presented. When a substance capable of producing methionine through hydrolysis is used as raw material and converted into methionine by using a biocatalyst, the biocatalyst is repeatedly usable and the accumulation amount of methionine dissolved in the reaction solution is increased, and methionine is obtained in a solid form from the reaction solution. Specifically, the present invention relates to a method for producing methionine comprising the following steps: a first step of converting raw material capable of producing methionine through hydrolysis of 2-amino-4-methylthiobutyronitrile, and 2-amino-4-methylthiobutanamide or the like in an aqueous ammonia solution, into methionine-containing aqueous ammonia solution, with a biocatalyst through hydrolysis, a second step of separating the biocatalyst from the methionine-containing aqueous ammonia solution obtained in the first step, and a third step of distilling ammonia out of the methionine-containing aqueous ammonia solution separated in the second step to deposit and separate crystals of methionine.
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Description

technical field

[0001] The present invention relates to a method for preparing methionine crystals used as pharmaceuticals or feed additives. Methionine is required especially in the feed additive market in solid (crystalline) form. Background technique

[0002] As a method for preparing 2-amino acids utilizing the nitrile hydrolysis activity of a biocatalyst, a method using 2-aminonitrile or 2-aminoamide as a raw material is known (Japanese Patent Publication No. 58-15120, Japanese Patent Publication No. 63-500004 , JP-2-31694, JP-3-500484, JP-3-16118, WO02 / 08439, JP-2002-34593, US-6417395) and a method using cyanohydrin as a raw material (JP Kaiping 9-140391). However, neither method discloses a practical method for efficiently separating and purifying a solid 2-amino acid having low water solubility such as methionine from a biocatalyst.

[0003] In addition, in the microbiological manufacture of glycine from glycylnitrile obtained by the reaction of formaldehyde, hydr...

Claims

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