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Sarcadra injection, its making method and venous injection

A technology of sarcophagus and injection, applied in the direction of antineoplastic drugs, antipyretics, anti-inflammatory agents, etc., can solve problems such as inconvenient use, muscle necrosis, congestion, etc., to avoid inconvenient use and high bioavailability , the effect of extending the validity period

Inactive Publication Date: 2005-10-12
诺氏制药(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the existing route of administration of Zhongjiefeng Injection is intramuscular injection, it is inconvenient to use clinically, the administration site of the patient is painful, and it is easy to cause adverse reactions such as congestion and even muscle necrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Take 1000g of sarcophagus, add 6 times the weight of sarcophagus, boil and decoct 2 times, each time for 2 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of liquid medicine containing 1g of crude drug; add to the concentrated solution Add 0.05% of the weight of the concentrated liquid clarifier B, heat to 70-90 ° C, let stand for 2 hours, then add 0.025% of the weight of the concentrated liquid clarifier A, let stand for 4 hours, centrifuge, and pour the supernatant and concentrated to 3g of crude drug per ml of medicinal liquid; add ethanol under slow stirring, add ethanol to make the alcohol content 75%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from the filtrate, and concentrate to per ml The medicinal solution contains 3g of crude drug, add ethanol to make the alcohol content 85%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from the filtrate, concentrate the filtra...

Embodiment 2

[0041] Get 2000g of sarcophagus, add 8 times the weight of sarcophagus, boil and decoct 2 times, each time for 3 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of medicinal solution containing 1.5g of crude drug; add to the concentrated solution Add 0.04% of the weight of the concentrated solution to the clarifier B, heat to 70-90 ° C, let it stand for 2 hours, then add 0.02% of the weight of the concentrated solution A clarifier, after standing for 4 hours, centrifuge, and the supernatant Pour out and concentrate to 4g of crude drug per ml of liquid medicine; add ethanol under slow stirring, add ethanol to make the alcohol content to 70%, refrigerate at 4-8°C for 48 hours, filter through filter paper, recover ethanol from the filtrate, and concentrate to every The medicinal solution in ml contains 4g of crude drug, add ethanol to make the alcohol content 80%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from ...

Embodiment 3

[0043] Take 5000g of sarcophagus, add 7 times the weight of sarcocarp, boil and decoct 2 times, each time for 2.5 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of liquid medicine containing 2g of crude drug; add to the concentrated solution Add 0.03% of the weight of the concentrated liquid clarifier B, heat to 70-90 ° C, let stand for 2 hours, then add 0.015% of the weight of the concentrated liquid clarifier A, let stand for 4 hours, centrifuge, and pour the supernatant and concentrated to 3.5 g of crude drug per ml of medicinal solution; adding ethanol under slow stirring, adding ethanol to make the alcohol content to 70%, refrigerating at 4-8°C for 48 hours, filtering through filter paper, recovering ethanol from the filtrate, and concentrating to every The medicinal solution in ml contains 3g of crude drug, add ethanol to make the alcohol content 80%, refrigerate at 4-8°C for 48 hours, filter through filter paper, recover ethanol from ...

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Abstract

The invention relates to Sarcadra injection, its making method and venous injection. The medicine is obtained by following steps (1-1000 weight portion original medicine material): boiling, concentrating, adding clarifier, alcohol-settling, water-settling, hyperfiltration to get Sarcadra active component, subpackaging, disinfecting to get preparation, in which the fumaric acid is less than 30 mumg / m. The injection has the function of inflammation-relieving, vein relaxing, blood activating for treating pneumonia, appendicitis, cellulitis, rheumatalgia, injuries from falls and auxiliary therapeutic treatment for cancer. The invention avoids the medicine liquid thickness, deposition and color changing, stabilizes the preparation, prolongs the product effective date. The injection can be applied through vein so as to prevent the adverse effects such as pain in the administration location, blood stasis and even muscle necrosis.

Description

field of invention [0001] The invention relates to a sarcophagus injection, a preparation method thereof and a sargassum injection for intravenous administration, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Zhongjiefeng, also known as Jiujiecha, Jiujiefeng, and Elderberry, is the whole plant of Chestnut Orchidaceae, a perennial evergreen herb or subshrub, and the whole plant is used as medicine; it is slightly warm in nature, bitter and pungent in taste; the main ingredients are Volatile oil (linalyl acetate, etc. in the oil) succinic acid, fumaric acid, coumarone, flavonoid glycosides, lactone, tannin, etc. Among them, volatile oil, succinic acid, fumaric acid, flavonoid glycosides, etc. are anti-tumor active ingredients. Shigella baumannii, typhoid bacillus, Escherichia coli, and Pseudomonas aeruginosa have strong inhibitory effects, and are used for the treatment of pneumonia, appendicitis, cellulitis, rheumatic arth...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61P11/00A61P29/00A61P35/00
Inventor 郭智华
Owner 诺氏制药(吉林)有限公司
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