Herba sarcandrae injection solution, preparation method thereof and intravenous administration herba sarcandrae injection thereof

A technology for injection and swollen joints, which is applied in the directions of antitumor drugs, antipyretics, anti-inflammatory agents, etc., can solve problems such as inconvenience of use, muscle necrosis, congestion, etc., to avoid inconvenience of use and high bioavailability. , the effect of extending the validity period

Inactive Publication Date: 2017-02-08
威海恒基伟业信息科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the existing route of administration of Zhongjiefeng Injection is intramuscular injection, it is inconvenient to use clinicall

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0038] Example 1

[0039]Take 1000g of sarcophagus, add 6 times the weight of sarcophagus, boil and decoct 2 times, each time for 2 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of liquid medicine containing 1g of crude drug; add to the concentrated solution Add 0.05% of the weight of the concentrated liquid clarifier B, heat to 70-90 ° C, let stand for 2 hours, then add 0.025% of the weight of the concentrated liquid clarifier A, let stand for 4 hours, centrifuge, and pour the supernatant and concentrated to 3g of crude drug per ml of medicinal liquid; add ethanol under slow stirring, add ethanol to make the alcohol content 75%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from the filtrate, and concentrate to per ml The medicinal solution contains 3g of crude drug, add ethanol to make the alcohol content 85%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from the filtrate, co...

Example Embodiment

[0040] Example 2

[0041] Get 2000g of sarcophagus, add 8 times the weight of sarcophagus, boil and decoct 2 times, each time for 3 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of medicinal solution containing 1.5g of crude drug; add to the concentrated solution Add 0.04% of the weight of the concentrated solution to the clarifier B, heat to 70-90 ° C, let it stand for 2 hours, then add 0.02% of the weight of the concentrated solution A clarifier, after standing for 4 hours, centrifuge, and the supernatant Pour out and concentrate to 4g of crude drug per ml of liquid medicine; add ethanol under slow stirring, add ethanol to make the alcohol content to 70%, refrigerate at 4-8°C for 48 hours, filter through filter paper, recover ethanol from the filtrate, and concentrate to every The medicinal solution in ml contains 4g of crude drug, add ethanol to make the alcohol content 80%, refrigerate at 4-8°C for 48 hours, filter with filter paper, r...

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PUM

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Abstract

The invention relates to a herba sarcandrae injection solution, a preparation method thereof and an intravenous administration herba sarcandrae injection thereof, and belongs to the field of traditional Chinese medicine preparations. The herba sarcandrae injection solution is prepared through the following steps: taking 1 to 1000 parts by weight of crude drugs; carrying out decocting, concentrating, addition of a clarifying agent, alcohol precipitation, water precipitation and ultrafiltration, thus obtaining active components of herba sarcandrae; subpackaging and sterilizing, thus obtaining the herba sarcandrae injection solution, wherein each ml of the herba sarcandrae injection solution contains a fumaric acid which is not less than 30 mu g. The herba sarcandrae injection solution disclosed by the invention has the functions of resisting bacteria, diminishing inflammation, dispelling wind, dredging collaterals, activating blood and eliminating stagnation, is used for treating diseases of pneumonia, appendicitis, phlegmon, rheumatic arthralgia, traumatic injury and the like, and can be used for adjuvant therapy of cancer. The herba sarcandrae injection solution can be administrated through an intravenous way, the bioavailability is high, the use is simple and convenient, adverse effects are few, and the adverse effects that blood stasis or even muscle necrosis and the like which are easily caused by inconvenience in clinical use and pain of a medicine administration position of a patient can be avoided.

Description

technical field [0001] The invention relates to a sarcophagus injection, a preparation method thereof and a sargassum injection for intravenous administration, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Zhongjiefeng, also known as Jiujiecha, Jiujiefeng, and Elderberry, is the whole plant of Chestnut Orchidaceae, a perennial evergreen herb or subshrub, and the whole plant is used as medicine; it is slightly warm in nature, bitter and pungent in taste; the main ingredients are Volatile oil (linalyl acetate, etc. in the oil) succinic acid, fumaric acid, coumarone, flavonoid glycosides, lactone, tannin, etc. Among them, volatile oil, succinic acid, fumaric acid, flavonoid glycosides, etc. are anti-tumor active ingredients. Shigella baumannii, typhoid bacillus, Escherichia coli, and Pseudomonas aeruginosa have strong inhibitory effects, and are used for the treatment of pneumonia, appendicitis, cellulitis, rheumatic arthral...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/08A61P31/04A61P11/00A61P1/00A61P1/12A61P17/02A61P29/00A61P35/00
CPCA61K36/185A61K9/0019A61K9/08A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 蔡颖
Owner 威海恒基伟业信息科技发展有限公司
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