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Mai-an dripping pill for treating hyperlipoproteinemia and its preparing method

A technology of hyperlipoproteinemia and Andi Pills, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, which can solve adverse overall health levels, adverse effects on improving patients' ability to seek medical treatment, and low dissolution rate, etc. Problems, to achieve the effect of being beneficial to labor protection and environmental protection, improving bioavailability, and accelerating dissolution and absorption

Inactive Publication Date: 2005-10-19
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
Granules also have relatively low drug content, which is inconvenient to take and other deficiencies
[0007] In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] Now with several groups of specific examples, the preparation method of Mai'an dripping pills of the present invention is further described:

[0028] Group 1: Tests with a single matrix

[0029] 1. Raw materials: according to the preparation method 1, first prepare the dry powder of the medicinal extract for later use;

[0030] 2. Substrate: polyethylene glycol (1000、2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;

[0031] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0032] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Mai'an Dropping Pills of different specifications.

[0033] [test results]

[0034] Experiment 1: In order to observe the difference in quality of the Mai'an drop pills prepared when the ratio of the drug extract to differe...

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PUM

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Abstract

The present invention relates to a kind of medicine composition, Mai'an dripping pill, with functions of lowering cholesterol and for treating hyperlipoproteinemia, etc. The present invention has high bioavailability, fast medicine release, fast acting, high effective content and low cost, and the production process has no pollution. The Mai'an dripping pill is prepared with northern haw and malt as Chinese medicinal materials and medicine carrier as matrix.

Description

technical field [0001] The present invention relates to a pharmaceutical composition which has the effect of lowering serum cholesterol and is used for the treatment of hyperlipoproteinemia and other diseases, in particular to a pharmaceutical composition prepared from the traditional Chinese medicine hawthorn and malt as raw materials together with a pharmaceutically acceptable carrier as a matrix A pharmaceutical composition oral preparation. Background technique [0002] According to the ministerial drug standard WS 3 - The pulse safety preparation prepared by the preparation method given in B-0115-89 is a kind of medicine that can lower serum cholesterol, prevent atherosclerosis, and also have a certain effect on lowering triglyceride and β-lipoprotein. It is used for Oral granules for the treatment of hyperlipoproteinemia and other diseases have been clinically verified and have definite curative effects. They are commonly used drugs for clinical and family treatment o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P3/06
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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