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Process for preparing anhydrous alcohol for medical use

An anhydrous ethanol, ethanol technology, applied in the preparation of organic compounds, chemical instruments and methods, preparation of hydroxyl compounds, etc., can solve the problems of complex equipment, large scale, large investment, etc., and achieve the effect of simple operation

Inactive Publication Date: 2005-11-23
杨振华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Toluene fractionation method, that is, add a certain amount of benzene (1 part of 95% ethanol plus 15-20 parts of benzene) to 95% ethanol to form a ternary system of ethanol-water-benzene, then distill in a water bath, and collect the distillate in sections Out of the liquid, when the temperature rises to 78.3 ° C, what is collected is absolute ethanol (about 0.05% benzene). Large, the catalyst used has not been produced in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1, 1. get 95% ethanol (edible alcohol) 1000ml, put in reaction tank, add phosphoric acid 14ml, increase the weight potassium chromate 2g shaking and make dissolving; The yellow fades. ③ Add 200g of calcium oxide and hang a cloth bag containing 30g of calcium chloride on the top of the flask, heat and reflux for 8 hours, then distill, discard the initial distillate, collect the distillate at 78.5°C, which is absolute ethanol, press the medicine Check with the standard and meet the regulations, it is medicinal anhydrous ethanol.

example 2

[0014] Example 2, ① Take about 1000ml of 95% ethanol (Chinese Pharmacopoeia standard), add 10ml of sulfuric acid, add 2.2g of potassium permanganate, ② keep warm at 55°C for 10 minutes, add 10% sodium pyrosulfite to make the color of potassium permanganate fade. ③Add 200g of calcium oxide, and hang a gauze bag containing 30g of calcium chloride on the top of the distillation bottle, heat and reflux for 8 hours, then distill, discard the initial distillate, collect the distillate at 78.5°C, and check it according to the medicinal standard , in line with the regulations is medicinal anhydrous ethanol.

example 3

[0015] Example 3, ① Take about 95% ethanol (edible alcohol) 1000ml, add phosphoric acid 14ml, add potassium permanganate 2.2g, ② keep warm at 30°C for 20 minutes, add 10% sodium pyrosulfite to make the color of potassium permanganate fade. ③Add 200g of calcium oxide and hang a gauze bag containing 30g of calcium chloride on the top of the retort, heat and reflux for 6 hours. Then distill, discard the initial distillate, collect the distillate at 78.5°C, check according to the pharmaceutical standards, and if it meets the regulations, it is medicinal anhydrous ethanol.

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PUM

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Abstract

The invention relates to a process for preparing anhydrous alcohol for medical use which comprises the steps of, (1) loading 95% of ethanol into reaction pot, charging oxidizing agent by the amount of 1-10g of oxidizing agent for 10L of 95% ethanol, wherein the oxidizing agent is any one agent selected from hypermanganate, manganese dioxide, bichromate, chromate, chromium trioxide, (2) thermal insulating 10-50 minutes at 25-55 deg. C, then charging sodium metabisulfite till the color of the oxidizing agent disappears, (3) charging calcium oxide into reaction pot by the amount of 1.5-2.5kg of calcium oxide for 10L of 95% ethanol, steam heating and backwashing 3-10 hours, (4) cooling the reaction pot and distilling, arranging a cloth bag containing calcium chloride above the reaction pot, thermally distilling, abandoning the first distillation liquid, gathering the distillate at 78.5 deg C.

Description

1. Technical field [0001] The invention belongs to a preparation method of medicinal absolute ethanol. 2. Background technology [0002] Absolute ethanol and its injection are the varieties recorded in USP, from USP22 (1990) to the current USP28. And there is no medicinal absolute ethanol and its injection in my country. [0003] At present, the literature data on producing dehydrated ethanol from 95% (ml / ml) ethanol only pays attention to removing moisture, and do not investigate the quality of dehydrated alcohol. "Henan Science and Technology" magazine 1995 (3): 16 disclosed the dehydrated ethanol production technology invented by Li Yuping, and introduced three methods for preparing dehydrated ethanol. 1. Lime-Calcium Chloride Method, that is, quicklime (GaO) and 95% alcohol are co-heated and refluxed, and then the distillate is collected. During the distillation process, a cloth bag containing calcium chloride is placed on the top of the distillation bottle to absorb ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C31/08
Inventor 杨振华
Owner 杨振华
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