Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process

A technology for medicines and crude drugs, applied in the field of preparation of transdermal medicines, can solve the problems of small drug loading, affecting the therapeutic effect, etc., and achieve the effect of high safety

Inactive Publication Date: 2005-12-14
杨小林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The film, one of the modern transdermal pharmaceutical preparations, has the biggest disadvantage of small drug loading. If the drug ingredients are not easy to penetrate the skin, it will seriously affect the therapeutic effect

Method used

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  • Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process
  • Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process
  • Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Extraction and preparation of various volatile oils and medicinal liquids used in the present invention

[0031] Method A and Method B extract the volatile oil of ginger, orange peel, and cloves by "Pharmacopoeia of the People's Republic of China" (2000 edition, one) appendix XD volatile oil determination.

[0032] Take an appropriate amount of ginger, chop it up, and obtain ginger volatile oil (equivalent to 25 g / ml of ginger raw medicine) by steam distillation.

[0033] Take an appropriate amount of orange peel, chop it up, and obtain orange peel volatile oil (equivalent to orange peel crude drug 15g / ml) by steam distillation.

[0034] Take an appropriate amount of cloves, crush them into coarse powder, and obtain cloves volatile oil (equivalent to cloves crude drug 10g / ml) by steam distillation.

[0035] Take an appropriate amount of Magnolia officinalis, crush it into a coarse powder, and decoct it with water to obtain a Magnolia officinalis extract (equivalent to ...

Embodiment 2

[0040] 1. Magnolia officinalis medicinal film, Danshen medicinal film, blank film and the preparation of magnolia bark and Danshen mixed medicinal film with different penetration-enhancing materials

[0041] ①Preparation of magnolia bark medicinal film: accurately weigh 5ml of magnolia bark extract (equivalent to 10g of magnolia bark crude drug) and place it in a container, add 10 drops each of glycerin and Tween-80 while grinding, and make a suspension for use . The swollen polyvinyl alcohol is referred to as PVA 1788 (3.5g) and CMCNa (1.5g) were mixed with the drug extract, and ground on a water bath at 65°C until uniform. Then prepare to 200cm 2 Magnolia officinalis medicinal film (thickness is about 1mm), after setting room temperature to dry naturally (or through 40 ℃ oven drying), promptly obtains Magnolia bark medicinal film.

[0042] ②Preparation of Danshen drug film: Accurately weigh 5ml of Salvia miltiorrhiza extract (equivalent to 5g of Danshen crude drug) and pl...

Embodiment 3

[0051] Magnolia bark dimethyl sulfoxide mixed membrane prescription: Magnolia officinalis extract equivalent to 10g of magnolia bark crude drug, 0.5ml dimethyl sulfoxide as penetration-promoting material, 0.5ml glycerin, 0.5ml Tween-80, 3.5g PVA1788, 1.5 g CMCNa.

[0052] Preparation method: Accurately weigh 5ml of magnolia bark extract (equivalent to 10g of magnolia bark crude drug) and place it in a container, add 10 drops each of dimethyl sulfoxide, glycerin and Tween-80 while grinding, and make a suspension for use . Take the swollen PVA 1788 (3.5g) and CMCNa (1.5g) were mixed with the drug extract, and ground on a water bath at 65°C until uniform. Then prepare to 200cm 2 The dimethyl sulfoxide mixed film of magnolia bark was obtained after drying naturally at room temperature (or drying in an oven at 40°C).

[0053] Magnolia officinalis dimethyl sulfoxide coating film prescription: Magnolia officinalis extract equivalent to 10g of magnolia bark crude drug, 0.5ml of di...

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Abstract

The present invention adopts volatile oil of plant, such as ginger, orange peel and clove as the material for promoting transdermal permeation of medicine, including magnolia bark medicine membrane as the exhaustion promoter to promote post-operation gastrointestinal peristalsis and red sage medicine membrane for local promoting blood circulation to disperse blood clots to treat scapulohumeral periarthritis and femoral head necrosis. The material for promoting transdermal permeation of medicine of the present invention has higher transdermal permeation promoting effect and less irritation to skin compared with available material.

Description

technical field [0001] The present invention originates from the research content of the extracurricular "early training" activity organized by Jiangsu Youth Science and Technology Activity Center in 2004, which the inventor participated in. The present invention relates to a penetration-promoting material derived from traditional Chinese medicine, a transdermal medicine containing the penetration-promoting material and a preparation method, specifically Chinese medicine volatile oil used as a penetration-promoting material of modern transdermal pharmaceutical preparations, a modern transdermal medicine containing Chinese medicine volatile oil, and a traditional Chinese medicine A method for using volatile oil as a penetration-enhancing material in the preparation of transdermal drugs. Background technique [0002] Modern transdermal drug preparations emerged in the 1980s, which allow drugs to enter specific sites in the body directly through the skin barrier, thereby avoidi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44
Inventor 杨小林
Owner 杨小林
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