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Combined medicine of diammonium glycyrhetate and its preparing method

A technology of diammonium glycyrrhizinate and licorice extract, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as difficulty in determining the end point of treatment, and achieve the effect of inhibiting free radicals and lipid peroxides. Production and formation, wide-ranging therapeutic effect, effect of preventing fibrosis of collagen fibers

Inactive Publication Date: 2005-12-21
张哲峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lamivudine is a nucleoside analogue with similar antiviral and antihepatitis effects, but it is difficult to determine the treatment endpoint, and after 1 year of treatment, only 15% to 20% of cases achieve a sustained antiviral response

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: powder injection preparation method

[0015] Prescription: (based on 1000 sticks)

[0016] Diammonium Glycyrrhizinate 40g

[0017] Cysteine ​​hydrochloride 30g

[0018] Glycine 400g

[0019] Anhydrous sodium sulfite 40g

[0020] Edetate Disodium 4g

[0021] Add water for injection to 2000ml

[0022] Made 1000 pieces

[0023]Weigh each component of the prescribed amount into the liquid dispensing tank, add an appropriate amount of water for injection, stir to dissolve them all, adjust the pH value to 5.5-7.5 with 0.1M hydrochloric acid or 0.1M sodium hydroxide solution, and then set the pH value with water for injection. Make up to the full prescription amount. Add 0.1% (g / ml) activated carbon in the prescribed amount to the medicinal liquid, stir at room temperature for about 30 minutes, and decarburize by plate-and-frame filtration. Pass through 1.0μm, 0.45μm, 0.2μm sterile filter membranes in turn. Check the clarity and pH value of the filtrate...

Embodiment 2

[0024] Embodiment 2: preparation method of water injection

[0025] Prescription: (based on 1000 sticks)

[0026] Diammonium Glycyrrhizinate 120g

[0027] Cysteine ​​Hydrochloride 90g

[0028] Glycine 1.2kg

[0029] Anhydrous sodium sulfite 90g

[0030] Edetate Disodium 10g

[0031] Add water for injection to 5000ml

[0032] Made 1000 pieces

[0033] Weigh each component of the prescribed amount into the liquid dispensing tank, add an appropriate amount of water for injection, stir to dissolve them all, adjust the pH value to 5.5-7.5 with 0.1M hydrochloric acid or 0.1M sodium hydroxide solution, and then set the pH value with water for injection. Make up to the full prescription amount. Add 0.1% (g / ml) activated carbon in the prescribed amount to the medicinal liquid, stir at room temperature for about 30 minutes, and decarburize by plate-and-frame filtration. Pass through 1.0μm, 0.45μm, 0.2μm sterile filter membranes in turn. Check the clarity and pH value of the f...

Embodiment 3

[0034] Embodiment 3: preparation method of transfusion

[0035] Diammonium Glycyrrhizinate 120g

[0036] Cysteine ​​Hydrochloride 90g

[0037] Glycine 1.2kg

[0038] Anhydrous sodium sulfite 90g

[0039] Edetate Calcium Sodium 10g

[0040] Glucose 2500g

[0041] Add water for injection to 50000ml

[0042] Makes 1000 bottles

[0043] Weigh each component of the prescribed amount into the liquid dispensing tank, add an appropriate amount of water for injection, stir to dissolve them all, adjust the pH value to 5.5-7.5 with 0.1M hydrochloric acid or 0.1M sodium hydroxide solution, and then set the pH value with water for injection. Make up to the full prescription amount. Add 0.1% (g / ml) activated carbon in the prescribed amount to the medicinal liquid, stir at room temperature for about 30 minutes, and decarburize by plate-and-frame filtration. Pass through 1.0μm, 0.45μm, 0.2μm sterile filter membranes in turn. Check the clarity and pH value of the filtrate, and deter...

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PUM

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Abstract

The present invention relates to a compound medicine formed from diammonium glycyrrhizinate and one or several kinds of halfcystine, glycine, methionine and vitamin B1. Its therapeutic action is extensive, and side effect is low. Said compound medicine can be used for curing the liver diseases of acuter, chronic and virus hepatitises, cirrhosis and fatty liver, etc. and can be used for improving function of liver and cholestasis in the liver. Besides, it also can be used for auxiliary therapy of alcoholism and barbitones and sulfonamides drug poisoning.

Description

technical field [0001] The invention relates to a medicine for treating or preventing liver disease-combined medicine containing diammonium glycyrrhizinate and a preparation method thereof. Background technique [0002] my country is a high-incidence area of ​​viral hepatitis. According to relevant data, there are more than 120 million chronic hepatitis B surface antigen carriers in my country, and no less than 12 million chronic persistent and chronic active hepatitis, which seriously threatens the health of the people. healthy. Up to now, most of the drugs clinically used to treat hepatitis are interferon-a, thymosin-a-1, lamivudine, etc. These medicines have certain curative effect clinically, but also have deficiency. For example, interferon α is effective for children with chronic hepatitis B, but it has a certain impact on children's growth. Interferon has relatively large side effects, as well as the disadvantages of being disabled for decompen...

Claims

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Application Information

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IPC IPC(8): A61K31/704
Inventor 张哲峰
Owner 张哲峰
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