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Method for producing substituted benzyl alcohol by continuous process and its apparatus

A technology of benzyl alcohol and benzyl halide, which is applied in the production field of replacing benzyl alcohol, can solve the problems of large alkali consumption, and achieve the effect of reducing waste discharge and resource consumption

Inactive Publication Date: 2005-12-21
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as the benzyl chloride continuous alkali hydrolysis process of US4474993 need consume a large amount of alkali, produce salt and waste water

Method used

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  • Method for producing substituted benzyl alcohol by continuous process and its apparatus
  • Method for producing substituted benzyl alcohol by continuous process and its apparatus
  • Method for producing substituted benzyl alcohol by continuous process and its apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The raw material substituted benzyl chloride 1 and water are mixed in the mixer M and heated to 80°C, then fed continuously from the top of the reactor R by a pump, and the volume ratio of the substituted benzyl halide to water is 1:15. The temperature in the reactor is controlled at 120-150°C. Reactor R is a tubular constant temperature reactor filled with inert fillers (such as glass beads). The aspect ratio of the reactor is 1:3, and the pressure is controlled at 0.4MPa. The raw material substituted benzyl chloride 1 is evenly sprayed on the filler through the distributor at the top of the reactor R (for evenly distributing the material on the filler), and at the same time, water vapor 2 is introduced from the top of the reactor, and the substituted benzyl chloride 1 passes through reactor. The raw material substituted benzyl chloride 1 is distributed on the inert filler in the reactor in a liquid state to form a trickle bed, which increases the mass transfer area ...

Embodiment 2

[0055] The raw material substituted benzyl bromide 1 and water are mixed in the mixer M and heated to 80°C, then fed continuously from the top of the reactor R by a pump, and the volume ratio of substituted benzyl halide to water is 1:5. The temperature in the reactor is controlled at 160-180°C. Reactor R is a tubular constant temperature reactor filled with inert fillers (such as Raschig rings). The aspect ratio of the reactor is 1:7, and the pressure is controlled at 0.2MPa. The raw material substituted benzyl bromide 1 is evenly sprayed on the filler through the distributor at the top of the reactor R, and at the same time, water vapor 2 is introduced from the top of the reactor, and the substituted benzyl bromide 1 passes through the reactor R in parallel. The raw material substituted benzyl bromide 1 is distributed on the inert filler in the reactor in a liquid state to form a trickle bed, which increases the mass transfer area and improves the mass transfer efficiency; ...

Embodiment 3

[0059] Example 3: Preparation of 2-chlorobenzyl alcohol by hydrolysis of 2-chlorobenzyl chloride

[0060] Referring to the method of Example 1 (unmentioned parameters are the same as Example 1), heat 2-chlorobenzyl chloride and water (volume ratio 1:1) to 80° C., mix well, and pass through a metering pump at a space velocity of 0.2h -1 Entering the trickle bed reactor, the reactor R controls the temperature at 130-135°C and the pressure at 0.15MPa. Reactor R is filled with Raschig rings with a volume of 1L. Water vapor is introduced from the top of the reactor R with a space velocity of 0.6h -1 . The oil phase (that is, the organic phase) after passing through the bed of the reactor R can be determined to contain 86% substituted benzyl alcohol, 4% dibenzyl ether and 10% aqueous hydrochloric acid solution containing 2.6%.

[0061] The reactant is cooled to 30°C through the condenser L, and added to the continuous extraction tank E, and the extraction agent toluene is added a...

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Abstract

This invention has disclosed a kind of continuously producing method for substituted benzyl alcohol and its device. Mix substituted benzyl halogen and water, the mixture and steam pass the trickle-bed reactor side-by-side, hydrolyzing and separating continuously, producing substituted benzyl alcohol. This device is trickle-bed reactor, including mixing device, reactor, condenser, heat exchanger, extraction reactor, evaporator, rectification tower. This method is simple and environmental protection, costs little, quality of production is high, could product continuously. This device is of simple structure and easy to operate.

Description

technical field [0001] The invention relates to a production method of substituted benzyl alcohol, in particular to a method for continuous production of substituted benzyl alcohol, and also relates to a device using the method. Background technique [0002] The use of substituted benzyl alcohols as multipurpose solvents, intermediates in fine organic synthesis, pharmaceutical additives and for the preparation of pharmaceutically and agrochemically active compounds is well known to those skilled in the art. For example, halogenated benzyl alcohols are used as synthetic intermediates of pyrethroids. [0003] The preparation of benzyl alcohol by hydrolysis reaction of benzyl halide under the action of alkali has been widely seen in published literature, such as Kirk-OthmerEncyclopedia of Chemical Technology, 5th ed., Jonh Weily & Sons, Inc., New York, 2001.Vol.6, pp .323~334. There are mainly two types of processes for producing benzyl alcohol from benzyl chloride. One is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C33/46
Inventor 李振江曹飞韦萍石玉瑚欧阳平凯
Owner NANJING UNIV OF TECH
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