Compound drop pills of Chinese angelica and its preparation method

A technology of angelica and compound recipes, applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, the bioavailability of the first-pass effect of the liver and intestines, and the overall health of the society. , to achieve the effect of improving bioavailability, high bioavailability, and drug safety

Inactive Publication Date: 2006-01-18
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the quality of the drug. Efficacy also directly affects the therapeutic effect
At the same time, conventional oral dosage forms often produce relatively large dust pollution during the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.
The production process of conventional oral preparations is also relatively complicated, and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0033] Now with several groups of specific examples, the preparation method of compound angelica dripping pill of the present invention is described further.

[0034] [Group 1: Trials with a single substrate]

[0035] 1. Raw materials: According to [Appendix], pre-prepared dry powder extracts containing active ingredients of 3 pure traditional Chinese medicines, such as angelica, chuanxiong, and safflower, are ready for use;

[0036] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0037] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0038] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain compound angelica dripping pills of different specifications.

[0039] [test results]

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PUM

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Abstract

The invention discloses a compound drop pill of Chinese angelica having the functions of activating blood circulation and removing stasis, removing phlegm and relieving pain, treating diseases including menorrhalgia, amenorrhea, traumatic injury and rheumatalgia. The aim of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate administration dosage, low price, no acute allergic reaction or adverse effect, and facilitated transportation and carrying. The drop pill is prepared from the extract containing the active constituent of the three Chinese medicinal herbs, i.e. Chinese angelica root, Ligusticum wallichii, safflower, and medicinal carrying agent as the base material.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition which has the effects of promoting blood circulation and dredging menstruation, eliminating phlegm and relieving pain, and is used for the treatment of dysmenorrhea, amenorrhea, tumbling injury, rheumatic arthralgia and other diseases. The extract of the active ingredient of the pure traditional Chinese medicine is an oral preparation of a pharmaceutical composition prepared as a raw material. Background technique [0002] According to the ministerial drug standard WS 3 -Compound Angelica Injection prepared according to the preparation method given in B-3905-98, is a kind of blood-activating and menstrual-activating, expectorant-relieving and pain-relieving effects, and is used for dysmenorrhea, amenorrhea, tumbling injury, rheumatic arthralgia and other diseases The pure Chinese medicine injection for treatment has been clinically verified and has definite curative effect. It is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K9/20A61P15/00A61P29/00A61P19/02
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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