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Method for preparing degradable polymers in use for embolus of lacrimal point

A technology of polymer materials and puncta, which is applied in the field of synthesis and preparation of punctum plugs, can solve problems such as irreversibility, scars, pain, etc., and achieve the effect of avoiding secondary surgery and making surgery easy

Inactive Publication Date: 2006-04-19
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The initial method of sealing the puncta is with thermal punctal cautery, which is simple and effective, but scarring, painful and irreversible

Method used

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  • Method for preparing degradable polymers in use for embolus of lacrimal point
  • Method for preparing degradable polymers in use for embolus of lacrimal point

Examples

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Effect test

Embodiment 1

[0025] Using D, L-lactic acid as raw material, add equimolar glycolic acid, after water removal treatment, add catalyst stannous octoate (0.8%), polymerize at 165°C and pressure 60Pa for 14 hours. After the reaction, tetrahydrofuran was added to dissolve, then methanol was added to precipitate and purify the product, and vacuum-dried to obtain PLGA in the form of white powder with a glass transition temperature of about 31°C. The obtained white powdery PLGA is melt-extruded, and the extrusion temperature is 180° C. to prepare such figure 1 The punctal plug is shown.

Embodiment 2

[0027] Using D, L-lactic acid and glycolic acid as raw materials, the molar ratio of D, L-lactic acid and glycolic acid is 40:60, after dehydration treatment, adding catalyst stannous chloride (0.5%), at 150°C and pressure 70Pa Next, polymerize for 18 hours. After the reaction, add N,N-dimethylformamide to dissolve, then add ethanol to precipitate and purify the product, and vacuum dry to obtain PLGA in the form of white powder with a glass transition temperature of about 31.5°C. The obtained white powdery PLGA is melt-extruded, and the extrusion temperature is 220 ° C to prepare such figure 1 The punctal plug is shown.

Embodiment 3

[0029] Using L-lactic acid as raw material, adding equimolar glycolic acid, after dehydration treatment, adding catalyst zinc oxide (0.8%), polymerizing at 180°C and pressure 50Pa for 14 hours. After the reaction was completed, chloroform was added to dissolve, then methanol was added to precipitate and purify the product, and vacuum-dried to obtain PLGA in the form of white powder with a glass transition temperature of about 33°C. The obtained white powdery PLGA was melt-extruded, and the extrusion temperature was 190° C. to prepare the following figure 1 The punctal plug is shown.

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Abstract

A degradable high-molecular material used for preparing the lacrimale suppositary to treat xerophthalmia is prepared from lactic acid, alcoholic acid and / or caprolactone through copolycondensating reaction or from lactide, glycollide and / or caprolactone through open-ring polymerizing. Its vitrification temp is 32 + / - 1 deg.C. It can be degradated into CO2 and H2O.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for preparing a degradable polymer material for punctal plugs, in particular to a synthesis and preparation of degradable punctal plug materials for treating dry eye. Preparation method of punctal plug. Background technique [0002] For any reason, the abnormal structure of the tear layer of the eyeball or the insufficient secretion of components in each layer can cause dry eye syndrome. Patients with dry eye syndrome are troubled by many symptoms. In mild cases, the symptoms are dry eyes, red eyes, burning sensation, and foreign body sensation. Or eye soreness, severe cases appear diffuse corneal epithelial punctate or flake staining. [0003] At present, there are many treatments for dry eye syndrome, mainly including: (1) eliminating the cause; (2) artificial tears; (3) physical therapy, such as hot compress, eyelid massage, etc.; (4) punctum or...

Claims

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Application Information

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IPC IPC(8): C08G63/06A61F9/00
Inventor 顾书英任杰
Owner TONGJI UNIV
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