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Notoginseng triol-saponin composition and its prepn and use

A technology of triol saponins and Panax notoginseng saponins is applied in the field of the purification of traditional Chinese medicine Panax notoginseng and its preparation, and achieves the effects of solvent safety, reducing whole blood viscosity and preventing thrombosis

Active Publication Date: 2006-05-17
CHENGDU HUASUN GRP INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is difficult for the pharmaceutical preparations based on this kind of Panax notoginseng saponins to exert a more targeted drug effect on specific diseases.

Method used

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  • Notoginseng triol-saponin composition and its prepn and use
  • Notoginseng triol-saponin composition and its prepn and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Use a universal pulverizer (purchased from Shanghai Tianhe Pharmaceutical Machinery Factory, model GF-300) to pulverize 150 kg of dry rhizomes of Sanqi (place of origin: Wenshan, Yunnan Province), to a particle size range of 10 mesh to 24 mesh Sanqi coarse powder, use 2 The concentration of twice the weight of the medicinal material is 60wt% ethanol soaked in the above-mentioned Panax notoginseng coarse powder and then filled into the percolation barrel, and the concentration of 15 times the weight of the medicinal material is 60wt% 7 alcohol to percolate the wet material, and the ethanol in the percolation liquid is recovered under reduced pressure Afterwards, Panax notoginseng total saponin alcoholic extract. The above-mentioned Panax notoginseng saponin alcohol extract was prepared into a solution of 10 times the weight of the medicinal material with purified water, and the resulting aqueous solution was loaded onto the column of styrene-type macroporous resin D140 (p...

Embodiment 2～4

[0046] According to the same method and steps as described in Example 1, ethanol with different concentrations and different weights was used to soak, percolate and elute the Panax notoginseng coarse powder to obtain the following composition of the present invention, and the results are shown in Table 2 below Show:

[0047] Example

Embodiment 5

[0049] Get the dry PTS 100g that embodiment 1 makes, use the acetic acid buffer solution that pH value is 6 to be mixed with 2.5L solution, the gained solution is loaded on weakly basic anion exchange resin BS-II (purchased from Chengdu Zhonglan Chenguang Chemical Industry Co., Ltd. Research Institute) column, the volume of the resin column is 6L, eluted with 12L of acetic acid buffer solution with a pH value of 6, the flow rate is 0.4 times the column volume / hour, the eluate is collected, and the obtained eluate is concentrated and dried to obtain 60g of powder A refined notoginseng triol saponin composition.

[0050] By high performance liquid chromatography, octadecylsilane bonded silica gel is used as a filler, acetonitrile-water (volume ratio is 19.5:80.5) is used as a mobile phase, and the detection wavelength is 210nm, and the PTS obtained in Example 5 is measured respectively. Middle Rg 1 content of 65wt%, Re content of 8wt%, R 1 The content is 20wt%. The moisture c...

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Abstract

The present invention belongs to the field of Chinese medicine, and is especially the purified product of notoginseng as one kind of Chinese medicinal materials and its preparation process and pharmaceutical use. The notoginseng triol-saponin composition obtained through purifying notoginseng consists of ginsenoside Rg1, ginsenoside Re and saponin R1 as main components, and contains ginsenoside Rg1 30-70 wt%, ginsenoside Re 4-15 wt% and saponin R1 7-25 wt%, with the total content of ginsenoside Rg1, ginsenoside Re and saponin R1 being up to 98 wt%. The notoginseng triol-saponin composition has obvious treating effect on vascular embolism diseases, and is used in preparing medicine for treating vascular embolism diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the purified product of the traditional Chinese medicine Panax notoginseng and its preparation method and pharmaceutical application. Background technique [0002] Panax notoginseng (Burk.) F.H.chen, also known as Tianqi, Panax notoginseng, Panax notoginseng, mountain lacquer, Jinbuhuan and blood ginseng, is a perennial herbaceous plant of the genus Panax Linn in the family Araliaceae , because it is excavated three to seven years after sowing and each plant has three petioles, and each petiole has seven leaves, so it is named Sanqi. Its stems, leaves, and flowers can be used as medicine. It is a unique and precious Chinese medicinal material in China. According to relevant documents, Panax notoginseng has been used for nearly 600 years and cultivated for nearly 500 years. Panax notoginseng is known as "gold does not change" and "sacred grass in the south...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K36/258A61P7/02A61P9/10
CPCA61K36/258A61P7/02A61P9/10
Inventor 万方袁毓湘李明劲
Owner CHENGDU HUASUN GRP INC LTD
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